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https://hdl.handle.net/2440/133510
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dc.contributor.author | Kelly, C.E. | - |
dc.contributor.author | Chan, L. | - |
dc.contributor.author | Burnett, A.C. | - |
dc.contributor.author | Lee, K.J. | - |
dc.contributor.author | Connelly, A. | - |
dc.contributor.author | Anderson, P.J. | - |
dc.contributor.author | Doyle, L.W. | - |
dc.contributor.author | Cheong, J.L.Y. | - |
dc.contributor.author | Thompson, D.K. | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Developmental Medicine and Child Neurology, 2015; 57(12):1168-1175 | - |
dc.identifier.issn | 0012-1622 | - |
dc.identifier.issn | 1469-8749 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133510 | - |
dc.description.abstract | To elucidate neurobiological changes underlying motor impairments in adolescents born extremely preterm (gestation <28wks) and/or with extremely low birthweight (ELBW, <1000g), our aims were the following: (1) to compare corticospinal tract (CST) microstructure and primary motor cortex (M1) volume, area, and thickness between extremely preterm/ELBW adolescents and a comparison group with normal birthweight (>2499g); (2) to compare CST microstructure and M1 volume, area, and thickness between extremely preterm/ELBW adolescents with cerebral palsy (CP), motor impairment without CP, and no motor impairment; and (3) to investigate associations between CST microstructure and M1 measures.This study used diffusion and structural magnetic resonance imaging to examine the CST and M1 in a geographical cohort of 191 extremely preterm/ELBW adolescents (mean age 18y 2.4mo [SD 9.6mo]; 87 males, 104 females) and 141 adolescents in the comparison group (mean age 18y 1.2mo [SD 9.6mo]; 59 males, 82 females).Extremely preterm/ELBW adolescents had higher CST axial, radial, and mean diffusivities and lower M1 thickness than the comparison group. Extremely preterm/ELBW adolescents with CP had higher CST diffusivities than non-motor-impaired extremely preterm/ELBW adolescents. CST diffusivities correlated with M1 volume and area.Extremely preterm/ELBW adolescents have altered CST microstructure, which is associated with CP. Furthermore, the results elucidate how CST and M1 alterations interrelate to potentially influence motor function in extremely preterm/ELBW adolescents. | - |
dc.description.statementofresponsibility | Claire E Kelly, Linda Chan, Alice C Burnett, Katherine J Lee, Alan Connelly, Peter J Anderson ... et. | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.rights | © 2015 Mac Keith Press. | - |
dc.source.uri | http://dx.doi.org/10.1111/dmcn.12854 | - |
dc.subject | Cohort Studies | - |
dc.subject.mesh | Motor Cortex | - |
dc.subject.mesh | Pyramidal Tracts | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Cerebral Palsy | - |
dc.subject.mesh | Movement Disorders | - |
dc.subject.mesh | Magnetic Resonance Imaging | - |
dc.subject.mesh | Diffusion Magnetic Resonance Imaging | - |
dc.subject.mesh | Cohort Studies | - |
dc.subject.mesh | Adolescent | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Infant, Extremely Low Birth Weight | - |
dc.subject.mesh | Infant, Extremely Premature | - |
dc.title | Brain structural and microstructural alterations associated with cerebral palsy and motor impairments in adolescents born extremely preterm and/or extremely low birthweight | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/dmcn.12854 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/491246 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/546519 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/628371 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1053787 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1012236 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1053609 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Anderson, P.J. [0000-0002-3730-4652] | - |
Appears in Collections: | Paediatrics publications |
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