Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/133538
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dc.contributor.author | Hatzi, K. | - |
dc.contributor.author | Jiang, Y. | - |
dc.contributor.author | Huang, C. | - |
dc.contributor.author | Garrett-Bakelman, F. | - |
dc.contributor.author | Gearhart, M.D. | - |
dc.contributor.author | Giannopoulou, E.G. | - |
dc.contributor.author | Zumbo, P. | - |
dc.contributor.author | Kirouac, K. | - |
dc.contributor.author | Bhaskara, S. | - |
dc.contributor.author | Polo, J.M. | - |
dc.contributor.author | Kormaksson, M. | - |
dc.contributor.author | MacKerell, A.D. | - |
dc.contributor.author | Xue, F. | - |
dc.contributor.author | Mason, C.E. | - |
dc.contributor.author | Hiebert, S.W. | - |
dc.contributor.author | Prive, G.G. | - |
dc.contributor.author | Cerchietti, L. | - |
dc.contributor.author | Bardwell, V.J. | - |
dc.contributor.author | Elemento, O. | - |
dc.contributor.author | Melnick, A. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Cell Reports, 2013; 4(3):578-588 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133538 | - |
dc.description.abstract | The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells and diffuse large B cell lymphomas (DLBCLs). Although BCL6 can recruit multiple corepressors, its transcriptional repression mechanism of action in normal and malignant B cells is unknown. We find that in B cells, BCL6 mostly functions through two independent mechanisms that are collectively essential to GC formation and DLBCL, both mediated through its N-terminal BTB domain. These are (1) the formation of a unique ternary BCOR-SMRT complex at promoters, with each corepressor binding to symmetrical sites on BCL6 homodimers linked to specific epigenetic chromatin features, and (2) the "toggling" of active enhancers to a poised but not erased conformation through SMRT-dependent H3K27 deacetylation, which is mediated by HDAC3 and opposed by p300 histone acetyltransferase. Dynamic toggling of enhancers provides a basis for B cells to undergo rapid transcriptional and phenotypic changes in response to signaling or environmental cues. | - |
dc.description.statementofresponsibility | Katerina Hatzi, Yanwen Jiang, Chuanxin Huang, Francine Garrett-Bakelman, Micah D.Gearhart, Eugenia G.Giannopoulou | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative WorksLicense, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source arecredited | - |
dc.source.uri | http://dx.doi.org/10.1016/j.celrep.2013.06.016 | - |
dc.subject | B-Lymphocytes | - |
dc.subject.mesh | B-Lymphocytes | - |
dc.subject.mesh | Cell Line, Tumor | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Mice | - |
dc.subject.mesh | DNA-Binding Proteins | - |
dc.subject.mesh | Signal Transduction | - |
dc.subject.mesh | Models, Molecular | - |
dc.subject.mesh | Proto-Oncogene Proteins c-bcl-6 | - |
dc.subject.mesh | Lymphoma, Large B-Cell, Diffuse | - |
dc.subject.mesh | Promoter Regions, Genetic | - |
dc.subject.mesh | Heterografts | - |
dc.title | A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.celrep.2013.06.016 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Polo, J.M. [0000-0002-2531-778X] | - |
Appears in Collections: | Medical Sciences publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_133538.pdf | Published version | 2.24 MB | Adobe PDF | View/Open |
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