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https://hdl.handle.net/2440/133667
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dc.contributor.author | Loh, W.Y. | - |
dc.contributor.author | Anderson, P.J. | - |
dc.contributor.author | Cheong, J.L.Y. | - |
dc.contributor.author | Spittle, A.J. | - |
dc.contributor.author | Chen, J. | - |
dc.contributor.author | Lee, K.J. | - |
dc.contributor.author | Molesworth, C. | - |
dc.contributor.author | Inder, T.E. | - |
dc.contributor.author | Connelly, A. | - |
dc.contributor.author | Doyle, L.W. | - |
dc.contributor.author | Thompson, D.K. | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Pediatric Research, 2017; 82(6):970-978 | - |
dc.identifier.issn | 0031-3998 | - |
dc.identifier.issn | 1530-0447 | - |
dc.identifier.uri | https://hdl.handle.net/2440/133667 | - |
dc.description.abstract | Background: This study aims to (i) compare volumes of individual basal ganglia nuclei (caudate nucleus, pallidum, and putamen) and the thalamus between very preterm (VP) and term-born infants at term-equivalent age; (ii) explore neonatal basal ganglia and thalamic volume relationships with 7-year neurodevelopmental outcomes, and whether these relationships differed between VP and term-born children. Methods: 210 VP (<30 weeks’ gestational age) and 39 term-born (≥37 weeks’ gestational age) infants underwent brain magnetic resonance imaging at term-equivalent age, and deep gray matter volumes of interest were automatically generated. 186 VP and 37 term-born children were assessed for a range of neurodevelopmental measures at age 7 years. Results: All deep gray matter structures examined were smaller in VP infants compared with controls at term-equivalent age; ranging from (percentage mean difference (95% confidence intervals) −6.2% (−10.2%, −2.2%) for the putamen, to −9.5% (−13.9%, −5.1%) for the caudate nucleus. Neonatal basal ganglia and thalamic volumes were positively related to motor, intelligence quotient, and academic outcomes at age 7 years, with mostly similar relationships in the VP and control groups. Conclusion: VP birth results in smaller basal ganglia and thalamic volumes at term-equivalent age, and these smaller volumes are related to a range of 7-year neurodevelopmental deficits in VP children. | - |
dc.description.statementofresponsibility | Wai Yen Loh, Peter J Anderson, Jeanie L Y Cheong, Alicia J Spittle, Jian Chen, Katherine J Lee ... et al. | - |
dc.language.iso | en | - |
dc.publisher | Springer Nature | - |
dc.rights | © 2017 International Pediatric Research Foundation, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1038/pr.2017.161 | - |
dc.subject | Central Nervous System | - |
dc.subject | Thalamus | - |
dc.subject | Basal Ganglia | - |
dc.subject | Humans | - |
dc.subject | Magnetic Resonance Imaging | - |
dc.subject | Neuropsychological Tests | - |
dc.subject | Child | - |
dc.subject | Infant, Newborn | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Infant, Extremely Premature | - |
dc.subject.mesh | Central Nervous System | - |
dc.subject.mesh | Thalamus | - |
dc.subject.mesh | Basal Ganglia | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Magnetic Resonance Imaging | - |
dc.subject.mesh | Neuropsychological Tests | - |
dc.subject.mesh | Child | - |
dc.subject.mesh | Infant, Newborn | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Infant, Extremely Premature | - |
dc.title | Neonatal basal ganglia and thalamic volumes: very preterm birth and 7-year neurodevelopmental outcomes | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/pr.2017.161 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/546519 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1060733 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/237117 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/491209 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1081288 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1108714 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1085754 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1053787 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Anderson, P.J. [0000-0002-3730-4652] | - |
Appears in Collections: | Paediatrics publications |
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