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https://hdl.handle.net/2440/134069
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Type: | Journal article |
Title: | Malaria parasite clearance: what are we really measuring? |
Author: | Khoury, D.S. Zaloumis, S.G. Grigg, M.J. Haque, A. Davenport, M.P. Cromer, D. Rebelo, M. Cao, P. McCaw, J.M. Simpson, J.A. Flegg, J.A. Wilson, D.W. Anstey, N.M. McCarthy, J.S. |
Citation: | Trends in Parasitology, 2020; 36(5):413-426 |
Publisher: | Elsevier |
Issue Date: | 2020 |
ISSN: | 1471-4922 1471-5007 |
Statement of Responsibility: | David S.Khoury, Sophie G.Zaloumis, Matthew J.Grigg, Ashraful Haque, Miles P.Davenport, The Interdisciplinary Approaches to Malaria Consortium |
Abstract: | Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires large clinical trials and thus we have identified proxy measures of drug efficacy such as the parasite clearance curve. This is often assumed to measure the rate of drug activity against parasites and is used to predict optimal treatment regimens required to completely clear a blood-stage infection. We discuss evidence that the clearance curve is not measuring the rate of drug killing. This has major implications for how we assess optimal treatment regimens, as well as how we prioritise new drugs in the drug development pipeline. |
Keywords: | Malaria; drug development; drug efficacy; parasite clearance |
Rights: | © 2020 Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.pt.2020.02.005 |
Grant ID: | http://purl.org/au-research/grants/arc/DP120100064 http://purl.org/au-research/grants/arc/DP180103875 http://purl.org/au-research/grants/arc/DE170100785 http://purl.org/au-research/grants/arc/DP170103076 http://purl.org/au-research/grants/nhmrc/1104975 http://purl.org/au-research/grants/nhmrc/1143974 http://purl.org/au-research/grants/nhmrc/1082022 http://purl.org/au-research/grants/nhmrc/1126399 http://purl.org/au-research/grants/nhmrc/1028641 http://purl.org/au-research/grants/nhmrc/1028643 http://purl.org/au-research/grants/nhmrc/1141921 http://purl.org/au-research/grants/nhmrc/1100394 http://purl.org/au-research/grants/nhmrc/1132975 http://purl.org/au-research/grants/nhmrc/1135820, http://purl.org/au-research/grants/nhmrc/1138860 http://purl.org/au-research/grants/nhmrc/1080001 |
Published version: | http://dx.doi.org/10.1016/j.pt.2020.02.005 |
Appears in Collections: | Environment Institute publications |
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