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https://hdl.handle.net/2440/134236
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Type: | Journal article |
Title: | Breaking constraint of mammalian axial formulae |
Author: | Hauswirth, G.M. Garside, V.C. Wong, L.S.F. Bildsoe, H. Manent, J. Chang, Y.-C. Nefzger, C.M. Firas, J. Chen, J. Rossello, F.J. Polo, J.M. McGlinn, E. |
Citation: | Nature Communications, 2022; 13(1):1-12 |
Publisher: | Springer Nature |
Issue Date: | 2022 |
ISSN: | 2041-1723 2041-1723 |
Statement of Responsibility: | Gabriel M. Hauswirth, Victoria C. Garside, Lisa S.F. Wong, Heidi Bildsoe, Jan Manent, Yi-Cheng Chang, Christian M. Nefzger, Jaber Firas, Joseph Chen, Fernando J. Rossello, Jose M. Polo, Edwina McGlinn |
Abstract: | The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral elements that form (known as axial formulae). The genetic mechanism(s) underlying this constraint however remain ill-defined. Here, we reveal the interplay of three regulatory pathways (Gdf11, miR-196 and Retinoic acid) is essential in constraining total vertebral number and regional axial identity in the mouse, from cervical through to tail vertebrae. All three pathways have differing control over Hox cluster expression, with heterochronic and quantitative changes found to parallel changes in axial identity. However, our work reveals an additional role for Hox genes in supporting axial elongation within the tail region, providing important support for an emerging view that mammalian Hox function is not limited to imparting positional identity as the mammalian body plan is laid down. More broadly, this work provides a molecular framework to interrogate mechanisms of evolutionary change and congenital anomalies of the vertebral column. |
Keywords: | Spine Tail Animals Mammals Mice Tretinoin Homeodomain Proteins Bone Morphogenetic Proteins MicroRNAs Body Patterning Genes, Homeobox Growth Differentiation Factors Biological Evolution Transcriptome |
Rights: | © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
DOI: | 10.1038/s41467-021-27335-z |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1051792 http://purl.org/au-research/grants/arc/DP180102157 |
Published version: | http://dx.doi.org/10.1038/s41467-021-27335-z |
Appears in Collections: | Medical Sciences publications |
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hdl_134236.pdf | Published version | 4.92 MB | Adobe PDF | View/Open |
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