Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134423
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Type: | Journal article |
Title: | Host-directed therapy, an untapped opportunity for antimalarial intervention |
Author: | Wei, L. Adderley, J. Leroy, D. Drewry, D.H. Wilson, D.W. Kaushansky, A. Doerig, C. |
Citation: | Cell Reports Medicine, 2021; 2(10):100423-1-100423-13 |
Publisher: | Elsevier |
Issue Date: | 2021 |
ISSN: | 2666-3791 2666-3791 |
Statement of Responsibility: | Ling Wei, Jack Adderley, Didier Leroy, David H. Drewry, Danny W. Wilson, Alexis Kaushansky and Christian Doerig |
Abstract: | Host-directed therapy (HDT) is gaining traction as a strategy to combat infectious diseases caused by viruses and intracellular bacteria, but its implementation in the context of parasitic diseases has received less attention. Here, we provide a brief overview of this field and advocate HDT as a promising strategy for antimalarial intervention based on untapped targets. HDT provides a basis from which repurposed drugs could be rapidly deployed and is likely to strongly limit the emergence of resistance. This strategy can be applied to any intracellular pathogen and is particularly well placed in situations in which rapid identification of treatments is needed, such as emerging infections and pandemics, as starkly illustrated by the current COVID-19 crisis. |
Keywords: | Malaria; antimalarial drug discovery; host-directed therapy |
Rights: | © 2021 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
DOI: | 10.1016/j.xcrm.2021.100423 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/2003712 |
Published version: | http://dx.doi.org/10.1016/j.xcrm.2021.100423 |
Appears in Collections: | Medical Sciences publications |
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hdl_134423.pdf | Published version | 1.22 MB | Adobe PDF | View/Open |
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