Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/134878
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Type: | Conference paper |
Title: | P450 catalysed dehydrogenation |
Author: | Wong, S.H. Bell, S.G. De Voss, J.J. |
Citation: | Pure and Applied Chemistry, 2017, vol.89, iss.6, pp.841-852 |
Publisher: | Walter de Gruyter |
Publisher Place: | Germany |
Issue Date: | 2017 |
ISSN: | 0033-4545 1365-3075 |
Conference Name: | International Conference on Physical Organic Chemistry (ICPOC-23 2016) (3 Jul 2016 - 8 Jul 2016 : Sydney) |
Statement of Responsibility: | Siew Hoon Wong, Stephen G. Bell and James J. De Voss |
Abstract: | Cytochrome P450s belong to a superfamily of enzymes that catalyse a wide variety of oxidative transformations. Hydroxylation is one the most thoroughly investigated of all identified P450-catalysed reactions whilst dehydrogenation has been relatively much less explored to date. P450-catalysed dehydrogenation is often found to occur with hydroxylation and thus, it was initially suspected to be a stepwise process consisting of hydroxylation and subsequent dehydration to yield the final olefin product. This theory has been proven to be invalid and the olefin was shown to be the direct product of a P450-catalysed reaction. This interesting reaction plays a vital role in the metabolism of xenobiotics and the biosynthesis of endogenous compounds, including a number of steroids. A number of well-known examples of P450 mediated dehydrogenation, including those in the metabolism of valproic acid, capsaicin and 3-methylindole and those in the biosynthesis of plant and fungal sterols are discussed in this review. |
Keywords: | biosynthesis; enzyme catalysis; ICPOC-23; metabolism; olefins; oxidation |
Rights: | © 2017 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
DOI: | 10.1515/pac-2016-1216 |
Grant ID: | http://purl.org/au-research/grants/arc/DP140103229 |
Published version: | https://www.degruyter.com/ |
Appears in Collections: | Chemistry publications |
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hdl_134878.pdf | Published version | 327.46 kB | Adobe PDF | View/Open |
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