Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/135747
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Type: | Journal article |
Title: | Effect of an antenatal diet and lifestyle intervention and maternal BMI on cord blood DNA methylation in infants of overweight and obese women: The LIMIT Randomised Controlled Trial |
Author: | Louise, J. Deussen, A.R. Koletzko, B. Owens, J. Saffery, R. Dodd, J.M. |
Citation: | PLoS One, 2022; 17(6) |
Publisher: | Public Library of Science (PLoS) |
Issue Date: | 2022 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Farrar, D. |
Statement of Responsibility: | Jennie Louise, Andrea R. Deussen, Berthold Koletzko, Julie Owens, Richard Saffery, Jodie M. Dodd |
Abstract: | Background: To investigate the effect of an antenatal diet and lifestyle intervention, and maternal prepregnancy overweight or obesity, on infant cord blood DNA methylation. Methods: We measured DNA methylation in 645 cord blood samples from participants in the LIMIT study (an antenatal diet and lifestyle intervention for women with early pregnancy BMI 25.0 kg/m2) using the Illumina 450K BeadChip array, and tested for any differential methylation related to the intervention, and to maternal early pregnancy BMI. We also analysed differential methylation in relation to selected candidate genes. Results: No CpG sites were significantly differentially methylated in relation to either the diet and lifestyle intervention, or with maternal early pregnancy BMI. There was no significant differential methylation in any of the selected genes related to the intervention, or to maternal BMI. Conclusion: We found no evidence of an effect of either antenatal diet and lifestyle, or of maternal early pregnancy BMI, on cord blood DNA methylation. |
Keywords: | Fetal Blood Humans Pregnancy Complications Obesity Body Mass Index Prenatal Care Diet Life Style DNA Methylation Pregnancy Infant Female Overweight |
Rights: | Copyright: © 2022 Louise et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0269723 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/519240 http://purl.org/au-research/grants/nhmrc/627005 http://purl.org/au-research/grants/nhmrc/1078980 http://purl.org/au-research/grants/nhmrc/1196133 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0269723 |
Appears in Collections: | Obstetrics and Gynaecology publications |
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hdl_135747.pdf | Published version | 618.17 kB | Adobe PDF | View/Open |
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