Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/136053
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, Y.W. | - |
dc.contributor.author | Zhou, Q.T. | - |
dc.contributor.author | Han, M.L. | - |
dc.contributor.author | Chen, K. | - |
dc.contributor.author | Onufrak, N.J. | - |
dc.contributor.author | Wang, J. | - |
dc.contributor.author | Turnidge, J.D. | - |
dc.contributor.author | Howden, B.P. | - |
dc.contributor.author | Forrest, A. | - |
dc.contributor.author | Chan, H.K. | - |
dc.contributor.author | Li, J. | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Antimicrobial Agents and Chemotherapy, 2018; 62(2):e01790-1-e0179-17 | - |
dc.identifier.issn | 0066-4804 | - |
dc.identifier.issn | 1098-6596 | - |
dc.identifier.uri | https://hdl.handle.net/2440/136053 | - |
dc.description.abstract | The pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. The area under the concentration-time curve over 24 h in the steady state divided by the MIC (AUC/MIC) in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin. | - |
dc.description.statementofresponsibility | Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J. Onufrak, Jiping Wang, John D. Turnidge, Benjamin P. Howden, Alan Forrest, Hak-Kim Chan, Jian Lih | - |
dc.language.iso | en | - |
dc.publisher | American Society for Microbiology | - |
dc.rights | © 2018 American Society for Microbiology. All Rights Reserved. | - |
dc.source.uri | http://dx.doi.org/10.1128/aac.01790-17 | - |
dc.subject | polymyxin; respiratory tract infections; pulmonary administration; Acinetobacter baumannii; Klebsiella pneumoniae; Gram-negative bacteria | - |
dc.subject.mesh | Lung | - |
dc.subject.mesh | Animals | - |
dc.subject.mesh | Mice | - |
dc.subject.mesh | Acinetobacter baumannii | - |
dc.subject.mesh | Klebsiella pneumoniae | - |
dc.subject.mesh | Acinetobacter Infections | - |
dc.subject.mesh | Respiratory Tract Infections | - |
dc.subject.mesh | Disease Models, Animal | - |
dc.subject.mesh | Colistin | - |
dc.subject.mesh | Anti-Bacterial Agents | - |
dc.subject.mesh | Microbial Sensitivity Tests | - |
dc.subject.mesh | Drug Resistance, Multiple, Bacterial | - |
dc.title | Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1128/AAC.01790-17 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1065046 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Turnidge, J.D. [0000-0003-4240-5578] | - |
Appears in Collections: | Medical Sciences publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.