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https://hdl.handle.net/2440/136120
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Type: | Journal article |
Title: | Negative ion cleavages of (M-H)(-) anions of peptides. Part 3. Post-translational modifications |
Author: | Wang, T. Nha Tran, T. Andreazza, H. Bilusich, D. Brinkworth, C. Bowie, J. |
Citation: | Mass Spectrometry Reviews, 2018; 37(1):3-21 |
Publisher: | Wiley |
Issue Date: | 2018 |
ISSN: | 0277-7037 1098-2787 |
Statement of Responsibility: | Tianfang Wang, T.T. Nha Tran, Hayley J. Andreazza, Daniel Bilusich, Craig S. Brinkworth, and John H. Bowie |
Abstract: | It is now 25 years since we commenced the study of the negative-ion fragmentations of peptides and we have recently concluded this research with investigations of the negative-ion chemistry of most post-translational functional groups. Our first negative-ion peptide review (Bowie, Brinkworth, & Dua, 2002) dealt with the characteristic backbone fragmentations and side-chain cleavages from (M-H)- ions of underivatized peptides, while the second (Bilusich & Bowie, 2009) included negative-ion backbone cleavages for Ser and Cys and some initial data on some post-translational groups including disulfides. This third and final review provides a brief summary of the major backbone and side chain cleavages outlined before (Bowie, Brinkworth, & Dua, 2002) and describes the quantum mechanical hydrogen tunneling associated with some proton transfers in enolate anion/enolate systems. The review then describes, in more depth, the negative-ion cleavages of the post-translational groups Kyn, isoAsp, pyroglu, disulfides, phosphates, and sulfates. Particular emphasis is devoted to disulfides (both intra- and intermolecular) and phosphates because of the extensive and spectacular anion chemistry shown by these groups. |
Keywords: | negative-ion electrospray mass spectrometry quantum mechanical hydrogen tunneling peptides ricin D post-translational modifications including kynurenine (Kyn) isoAspartate (isoAsp), pyroglutamate (pyroGlu) disulphides (both intra and intermolecular) phosphates, and sulfates |
Rights: | © 2016 by Wiley Periodicals, Inc. |
DOI: | 10.1002/mas.21501 |
Grant ID: | ARC |
Published version: | http://dx.doi.org/10.1002/mas.21501 |
Appears in Collections: | Earth and Environmental Sciences publications |
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