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https://hdl.handle.net/2440/136525
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Type: | Journal article |
Title: | Heritage-specific oral microbiota in Indigenous Australian dental calculus |
Author: | Handsley-Davis, M. Kapellas, K. Jamieson, L.M. Hedges, J. Skelly, E. Kaidonis, J. Anastassiadis, P. Weyrich, L.S. |
Citation: | Evolution, Medicine and Public Health, 2022; 10(1):352-362 |
Publisher: | Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health |
Issue Date: | 2022 |
ISSN: | 2050-6201 2050-6201 |
Statement of Responsibility: | Matilda Handsley-Davis, Kostas Kapellas, Lisa M. Jamieson, Joanne Hedges, Emily Skelly, John Kaidonis, Poppy Anastassiadis, and Laura S. Weyrich |
Abstract: | Background and objectives: Aboriginal Australians and Torres Strait Islanders (hereafter respectfully referred to as Indigenous Australians) experience a high burden of chronic non-communicable diseases (NCDs). Increased NCD risk is linked to oral diseases mediated by the oral microbiota, a microbial community influenced by both vertical transmission and lifestyle factors. As an initial step towards understanding the oral microbiota as a factor in Indigenous health, we present the first investigation of oral microbiota in Indigenous Australian adults. Methodology: Dental calculus samples from Indigenous Australians with periodontal disease (PD; n = 13) and non-Indigenous individuals both with (n = 19) and without PD (n = 20) were characterized using 16S ribosomal RNA gene amplicon sequencing. Alpha and beta diversity, differentially abundant microbial taxa and taxa unique to different participant groups were analysed using QIIME2. Results: Samples from Indigenous Australians were more phylogenetically diverse (Kruskal-Wallis H = 19.86, P = 8.3 × 10−⁶), differed significantly in composition from non-Indigenous samples (PERMANOVA pseudo-F = 10.42, P = 0.001) and contained a relatively high proportion of unique taxa not previously reported in the human oral microbiota (e.g. Endomicrobia). These patterns were robust to stratification by PD status. Oral microbiota diversity and composition also differed between Indigenous individuals living in different geographic regions. Conclusions and implications: Indigenous Australians may harbour unique oral microbiota shaped by their long relationships with Country (ancestral homelands). Our findings have implications for understanding the origins of oral and systemic NCDs and for the inclusion of Indigenous peoples in microbiota research, highlighting the microbiota as a novel field of enquiry to improve Indigenous health. |
Keywords: | Aboriginal Australian evolutionary medicine Indigenous Australian microbiome microbiota oral health |
Rights: | © The Author(s) 2022. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1093/emph/eoac024 |
Grant ID: | http://purl.org/au-research/grants/arc/FT180100407 http://purl.org/au-research/grants/nhmrc/627100 http://purl.org/au-research/grants/nhmrc/1113098 |
Published version: | http://dx.doi.org/10.1093/emph/eoac024 |
Appears in Collections: | Dentistry publications |
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