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https://hdl.handle.net/2440/136588
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Type: | Journal article |
Title: | Preclinical feasibility of robot-assisted sentinel lymph node biopsy using multi-modality magnetic and fluorescence guidance in the head and neck |
Author: | Krishnan, G. Cousins, A. Pham, N. Milanova, V. Nelson, M. Krishnan, S. van den Berg, N.S. Shetty, A. Rosenthal, E.L. Wormald, P.J. Thierry, B. Foreman, A. Krishnan, S. |
Citation: | Head and Neck: journal for the sciences and specialities of the head and neck, 2022; 44(12):2696-2707 |
Publisher: | Wiley |
Issue Date: | 2022 |
ISSN: | 1043-3074 1097-0347 |
Statement of Responsibility: | Giri Krishnan, Aidan Cousins, Nguyen Pham, Valentina Milanova, Melanie Nelson, Shridhar Krishnan, Nynke S. van den Berg, Anil Shetty, Eben L. Rosenthal, Peter-John Wormald, Benjamin Thierry, Andrew Foreman, Suren Krishnan |
Abstract: | Background: Sentinel lymph node biopsy (SLNB) is a staging procedure dependent on accurate mapping of draining lymphatics via tracers. Robotassisted SLNB enables access to multiple neck levels with a single incision and intraoperative fluorescence guidance to the SLN. Methods: Lymphatic mapping in swine was done using a magnetic tracer and fluorescent dye, injected into the tongue. MRI preoperatively mapped lymphatic spread of the magnetic tracer. Dissection was performed using a da Vinci Xi robot guided by fluorescence-imaging of the dye. Results: Robot-assisted SLNB was successfully performed in all animals (n = 5). A novel MRI protocol differentiated SLNs (n = 6) from lower echelon nodes (n = 11) based on flow progression. Fluorescence imaging provided valuable intraoperative guidance and correlated with magnetic-positive nodes. Conclusions: This study demonstrates preclinical feasibility of a robot-assisted approach to SLNB using magnetic and fluorescent tracers in the head and neck, enabling both preoperative mapping and intraoperative guidance. |
Keywords: | indocyanine green magnetic nanoparticles robotic surgery sentinel lymph node biopsy translational science |
Description: | First published: 08 September 2022 |
Rights: | © 2022 The Authors. Head & Neck published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
DOI: | 10.1002/hed.27177 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1158755 |
Published version: | http://dx.doi.org/10.1002/hed.27177 |
Appears in Collections: | Surgery publications |
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hdl_136588.pdf | Published version | 3.43 MB | Adobe PDF | View/Open |
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