Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/136984
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Type: | Journal article |
Title: | Leveraging a natural murine meiotic drive to suppress invasive populations |
Author: | Gierus, L. Birand, A. Bunting, M.D. Godahewa, G.I. Piltz, S.G. Oh, K.P. Piaggio, A.J. Threadgill, D.W. Godwin, J. Edwards, O. Cassey, P. Ross, J.V. Prowse, T.A.A. Thomas, P.Q. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2022; 119(46):1-11 |
Publisher: | National Academy of Sciences |
Issue Date: | 2022 |
ISSN: | 0027-8424 1091-6490 |
Statement of Responsibility: | Luke Gierusa, Aysegul Birandc, Mark D. Buntinga, Gelshan I. Godahewa, Sandra G. Piltz Kevin P. Oh, Antoinette J. Piaggio, David W. Threadgill, John Godwin, Owain Edwards, Phillip Cassey, Joshua V. Ross, Thomas A. A. Prowse and Paul Q. Thomas |
Abstract: | Invasive rodents are a major cause of environmental damage and biodiversity loss, particularly on islands. Unlike insects, genetic biocontrol strategies including populationsuppressing gene drives with biased inheritance have not been developed in mice. Here, we demonstrate a gene drive strategy (tCRISPR) that leverages super-Mendelian transmission of the t haplotype to spread inactivating mutations in a haplosufficient female fertility gene (Prl). Using spatially explicit individual-based in silico modeling, we show that tCRISPR can eradicate island populations under a range of realistic field-based parameter values. We also engineer transgenic tCRISPR mice that, crucially, exhibit biased transmission of the modified t haplotype and Prl mutations at levels our modeling predicts would be sufficient for eradication. This is an example of a feasible gene drive system for invasive alien rodent population control. |
Keywords: | genetic biocontrol; gene drive; invasive rodents; conservation; modeling |
Rights: | © 2022 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). |
DOI: | 10.1073/pnas.2213308119 |
Published version: | http://dx.doi.org/10.1073/pnas.2213308119 |
Appears in Collections: | Molecular and Biomedical Science publications |
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hdl_136984.pdf | Published version | 2.37 MB | Adobe PDF | View/Open |
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