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https://hdl.handle.net/2440/137192
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Type: | Journal article |
Title: | Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications |
Author: | Jolly, M.K. Murphy, R.J. Bhatia, S. Whitfield, H.J. Redfern, A. Davis, M.J. Thompson, E.W. |
Citation: | Cells, Tissues, Organs: in vivo, in vitro, 2022; 211(2):110-133 |
Publisher: | S. Karger AG |
Issue Date: | 2022 |
ISSN: | 1422-6405 1422-6421 |
Statement of Responsibility: | Mohit Kumar Jolly, Ryan J. Murphy, Sugandha Bhatia, Holly J. Whitfield, Andrew Redfern, Melissa J. Davis, Erik W. Thompson |
Abstract: | The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques. |
Keywords: | Epithelial-mesenchymal plasticity Epithelial-mesenchymal transition; Mesenchymal- epithelial transition; E/M hybrid Partial epithelial- mesenchymal plasticity Computational biology Molecular modelling Cancer |
Rights: | © 2021 S. Karger AG, Basel |
DOI: | 10.1159/000515289 |
Published version: | http://dx.doi.org/10.1159/000515289 |
Appears in Collections: | Medical Sciences publications |
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