Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/137950
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Type: Journal article
Title: Structured Back Focal Plane Interferometry (SBFPI)
Author: Upadhya, A.
Zheng, Y.
Li, L.
Lee, W.M.
Citation: Scientific Reports, 2019; 9(1):20273-1-20273-10
Publisher: Nature Publishing Group
Issue Date: 2019
ISSN: 2045-2322
2045-2322
Statement of
Responsibility: 
Avinash Upadhya, Yujie Zheng, Li Li, Woei Ming Lee
Abstract: Back focal plane interferometry (BFPI) is one of the most straightforward and powerful methods for achieving sub-nanometer particle tracking precision at high speed (MHz). BFPI faces technical challenges that prohibit tunable expansion of linear detection range with minimal loss to sensitivity, while maintaining robustness against optical aberrations. In this paper, we devise a tunable BFPI combining a structured beam (conical wavefront) and structured detection (annular quadrant photodiode). This technique, which we termed Structured Back Focal Plane Interferometry (SBFPI), possesses three key novelties namely: extended tracking range, low loss in sensitivity, and resilience to spatial aberrations. Most importantly, the conical wavefront beam preserves the axial Gouy phase shift and lateral beam waist that can then be harnessed in a conventional BFPI system. Through a series of experimental results, we were able to tune detection sensitivity and detection range over the SBFPI parameter space. We also identified a figure of merit based on the experimental optimum that allows us to identify optimal SBPFI configurations that balance both range and sensitivity. In addition, we also studied the resilience of SBFPI against asymmetric spatial aberrations (astigmatism of up to 0.8 λ) along the lateral directions. The simplicity and elegance of SBFPI will accelerate its dissemination to many associated fields in optical detection, interferometry and force spectroscopy.
Rights: © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI: 10.1038/s41598-019-56199-z
Grant ID: http://purl.org/au-research/grants/arc/DE160100843
http://purl.org/au-research/grants/arc/DP190100039
Published version: http://dx.doi.org/10.1038/s41598-019-56199-z
Appears in Collections:Biochemistry publications

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