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https://hdl.handle.net/2440/138568
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dc.contributor.author | Van Dam, J.M. | - |
dc.contributor.author | Graetz, L. | - |
dc.contributor.author | Pitcher, J.B. | - |
dc.contributor.author | Goldsworthy, M.R. | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Brain Research, 2023; 180:148359-1-148359-8 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | https://hdl.handle.net/2440/138568 | - |
dc.description.abstract | The neuroplastic response to continuous theta burst stimulation (cTBS) is inherently variable. The measurement of I-wave latencies has been shown to strongly predict the magnitude and direction of the response to cTBS, whereby longer latencies are associated with stronger long-term depression-like responses. However, potential differences in this association relating to age and sex have not been explored. We performed cTBS and measured I-wave recruitment (via MEP latencies) in 66 participants (31 female) ranging in age from 11 to 78 years. The influence of age and sex on the association between I-wave recruitment and the response to cTBS was tested using linear regression models. In contrast to previous studies, there was not a significant association between Iwave latencies and cTBS response at the group level (p = 0.142, R2 = 0.033). However, there were interactions between I-waves and both age and sex when predicting cTBS response. Subgroup analysis revealed that preferential late I-wave recruitment predicted cTBS response in adolescent females, but not in adolescent or adult males or adult females. These data suggest that the generalisability of I-wave measurement in predicting the response to cTBS may be lower than initially believed. Prediction models should include age and sex, rather than I-wave latencies alone, as our findings suggest that, while each factor alone is not a strong predictor, these factors interact to influence the response to cTBS. | - |
dc.description.statementofresponsibility | Jago M. Van Dam, Lynton Graetz, Julia B. Pitcher, Mitchell R. Goldsworthy | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 2023 Elsevier B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.brainres.2023.148359 | - |
dc.subject | transcranial magnetic stimulation | - |
dc.subject | continuous theta burst stimulation | - |
dc.subject | neuroplasticity | - |
dc.subject | I-waves | - |
dc.subject | sex | - |
dc.subject | neurodevelopment | - |
dc.subject.mesh | Motor Cortex | - |
dc.subject.mesh | Humans | - |
dc.subject.mesh | Linear Models | - |
dc.subject.mesh | Evoked Potentials, Motor | - |
dc.subject.mesh | Neuronal Plasticity | - |
dc.subject.mesh | Adolescent | - |
dc.subject.mesh | Adult | - |
dc.subject.mesh | Aged | - |
dc.subject.mesh | Middle Aged | - |
dc.subject.mesh | Child | - |
dc.subject.mesh | Female | - |
dc.subject.mesh | Male | - |
dc.subject.mesh | Transcranial Magnetic Stimulation | - |
dc.subject.mesh | Young Adult | - |
dc.title | The effects of age and biological sex on the association between I-wave recruitment and the response to cTBS: an exploratory study | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.brainres.2023.148359 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/1102272 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DE200100575 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Graetz, L. [0000-0001-9163-3150] | - |
dc.identifier.orcid | Goldsworthy, M.R. [0000-0002-0688-9475] | - |
Appears in Collections: | Molecular and Biomedical Science publications |
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