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https://hdl.handle.net/2440/1386
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Type: | Journal article |
Title: | Failure of presynaptic purinoceptors to modulate noradrenaline release from sympathetic nerves in human dental pulp |
Author: | Parker, D. Marino, V. Krishna, M. Polster, A. DeLaLande, I. |
Citation: | Archives of Oral Biology, 2000; 45(10):827-831 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2000 |
ISSN: | 0003-9969 1879-1506 |
Abstract: | The effects of putative presynaptic P1- and/or P2-purinoceptors on the release of noradrenaline from sympathetic nerves in human dental pulp were examined by testing the effects of agonists and an antagonist of these receptors on the stimulation-induced overflow of [(3)H]noradrenaline from tissue treated with desipramine (0.3 micromol/l) and preincubated with [(3)H]noradrenaline (0.6 micromol/l). The P1-purinoceptor agonists adenosine (1.0 mmol/l) and 2-chloroadenosine (0.01-1.0 mmol/l) and the antagonist 8-cyclopentyl-1,3-dipropyl xanthine (1.0 micromol/l), and the P2-purinoceptor agonists ATP (0.1 mmol/l) and beta, gamma-methylene-ATP (0.01 mmol/l), did not modulate the release of noradrenaline. Adenosine was also without effect in dental pulp treated with the alpha(2)-adrenoceptor antagonist rauwolscine. It is concluded that presynaptic P1-purinoceptors and those P2-purinoceptors activated by adenine nucleotides are either not present on sympathetic nerves in human dental pulp or that they exert little or no effect on the release of noradrenaline. |
Keywords: | Sympathetic Nervous System Dental Pulp Humans Tritium Norepinephrine Yohimbine Xanthines Desipramine Receptors, Purinergic P1 Receptors, Purinergic P2 Receptors, Presynaptic Adenosine 2-Chloroadenosine Adenine Nucleotides Adenosine Triphosphate Adrenergic alpha-Agonists Adrenergic alpha-Antagonists Adrenergic Uptake Inhibitors Sympathomimetics Radiopharmaceuticals Culture Techniques Purinergic P1 Receptor Agonists Purinergic P2 Receptor Agonists Purinergic P1 Receptor Antagonists Purinergic P2 Receptor Antagonists |
DOI: | 10.1016/S0003-9969(00)00059-5 |
Published version: | http://dx.doi.org/10.1016/s0003-9969(00)00059-5 |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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