Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/138654
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Type: | Journal article |
Title: | Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration |
Author: | Gerstweiler, L. Billakanti, J. Bi, J. Middelberg, A.P.J. |
Citation: | Journal of Chromatography A, 2022; 1667:462884-1-462884-8 |
Publisher: | Elsevier BV |
Issue Date: | 2022 |
ISSN: | 0021-9673 1873-3778 |
Statement of Responsibility: | Lukas Gerstweiler, Jagan Billakanti, Jingxiu Bi, Anton P.J. Middelberg |
Abstract: | Fluctuations of the inlet feed stream concentration are a challenge in controlling continuous multicolumn counter current chromatography systems with standard methods. We propose a new control strategy based on calculated product column breakthrough from UV sensor signals by neglecting an impurity baseline and instead using the impurity to product ratio. This calculation is independent of the inlet feed concentration. In-silico simulation showed that the proposed method can calculate the product column breakthrough perfectly even with fluctuating and highly unstable inlet feed concentration during a loading cycle. Applying the proposed method to control a three column periodic counter current chromatography process with fluctuating inlet feed concentration resulted in constant column loading in each cycle, while using the standard method failed to do so. Unavoidable band broadening caused by diffusion and dispersion has been identified as an inherent limiting factor for accurate calculation of column breakthrough comparing inlet and outlet UV signals. The proposed advanced calculations increase the robustness of periodic counter current chromatography and extend the capability to process unstable inlet streams. |
Keywords: | Periodic counter current chromatography; Continuous downstream processing; Controlling; Fluctuating concentration; Process integration |
Rights: | © 2022 Elsevier B.V. All rights reserved |
DOI: | 10.1016/j.chroma.2022.462884 |
Published version: | http://dx.doi.org/10.1016/j.chroma.2022.462884 |
Appears in Collections: | Aurora submissions |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S0021967322000826-main.pdf Restricted Access | Accepted version | 1.27 MB | Adobe PDF | View/Open |
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