A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium

Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/138689

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Type:	Journal article
Title:	A tetranuclear polypyridylruthenium(II) complex as a selective stain for extracellular vesicle penetration through brain microvascular endothelium
Author:	Wardhani, K. Levina, A. Sun, B. Grau, G.E.R. Keene, F.R. Collins, J.G. Lay, P.A.
Citation:	Chemical Communications, 2023; 59(45):6877-6880
Publisher:	Royal Society of Chemistry
Issue Date:	2023
ISSN:	1359-7345 1364-548X
Statement of Responsibility:	Kartika Wardhani, Aviva Levina, Biyun Sun, Georges E. R. Grau, F. Richard Keene, J. Grant Collins and Peter A. Lay
Abstract:	A new photoluminescent polypyridylruthenium(II) stain for extracellular vesicles (EVs) released from lipopolysaccharide-stimulated THP-1 monocytes enabled important new insights into how the bacteria-induced immune system affects the blood-brain barrier (BBB). These included previously unknown aspects of EV interactions with BBB microvascular endothelial cells and the extracellular matrix relevant to human brain diseases.
Keywords:	Blood-Brain Barrier Brain Endothelium Endothelial Cells Humans Extracellular Vesicles
Rights:	This journal is © The Royal Society of Chemistry 2023
DOI:	10.1039/d2cc05827h
Grant ID:	http://purl.org/au-research/grants/arc/DP180102741 http://purl.org/au-research/grants/arc/DP210101632 http://purl.org/au-research/grants/nhmrc/1099920
Published version:	http://dx.doi.org/10.1039/d2cc05827h
Appears in Collections:	Chemistry publications

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