Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/139197
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dc.contributor.author | Dagdeviren, S. | - |
dc.contributor.author | Hoang, M.F. | - |
dc.contributor.author | Sarikhani, M. | - |
dc.contributor.author | Meier, V. | - |
dc.contributor.author | Benoit, J.C. | - |
dc.contributor.author | Okawa, M.C. | - |
dc.contributor.author | Melnik, V.Y. | - |
dc.contributor.author | Ricci-Blair, E.M. | - |
dc.contributor.author | Foot, N. | - |
dc.contributor.author | Friedline, R.H. | - |
dc.contributor.author | Hu, X. | - |
dc.contributor.author | Tauer, L.A. | - |
dc.contributor.author | Srinivasan, A. | - |
dc.contributor.author | Prigozhin, M.B. | - |
dc.contributor.author | Shenoy, S.K. | - |
dc.contributor.author | Kumar, S. | - |
dc.contributor.author | Kim, J.K. | - |
dc.contributor.author | Lee, R.T. | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Journal of Biological Chemistry, 2023; 299(8):105045-1-105045-16 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://hdl.handle.net/2440/139197 | - |
dc.description.abstract | Glucagon signaling is essential for maintaining normoglycemia in mammals. The arrestin fold superfamily of proteins controls the trafficking, turnover, and signaling of transmembrane receptors as well as other intracellular signaling functions. Further investigation is needed to understand the in vivo functions of the arrestin domain–containing 4 (ARRDC4) protein family member and whether it is involved in mammalian glucose metabolism. Here, we show that mice with a global deletion of the ARRDC4 protein have impaired glucagon responses and gluconeogenesis at a systemic and molecular level. Mice lacking ARRDC4 exhibited lower glucose levels after fasting and could not suppress gluconeogenesis at the refed state. We also show that ARRDC4 coimmunoprecipitates with the glucagon receptor, and ARRDC4 expression is suppressed by insulin. These results define ARRDC4 as a critical regulator of glucagon signaling and glucose homeostasis and reveal a novel intersection of insulin and glucagon pathways in the liver | - |
dc.description.statementofresponsibility | Sezin Dagdeviren, Megan F. Hoang, Mohsen Sarikhani, Vanessa Meier, Jake C. Benoit, Marinna C. Okawa, Veronika Y. Melnik, Elisabeth M. Ricci-Blair, Natalie Foot, Randall H. Friedline, Xiaodi Hu, Lauren A. Tauer, Arvind Srinivasan, Maxim B. Prigozhin, Sudha K. Shenoy, Sharad Kumar, Jason K. Kim, and Richard T. Lee | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.rights | © 2023 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jbc.2023.105045 | - |
dc.subject | arrestin; glucagon; ARRDC4; gluconeogenesis; insulin; glucagon resistance | - |
dc.title | An Insulin-regulated Arrestin Domain Protein Controls Hepatic Glucagon Action | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jbc.2023.105045 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/GNT1122437 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/GNT2007739 | - |
dc.relation.grant | http://purl.org/au-research/grants/nhmrc/GNT1103006 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Foot, N. [0000-0002-6567-9283] | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
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hdl_139197.pdf | Published version | 1.93 MB | Adobe PDF | View/Open |
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