Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/139999
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Advancements in Acoustic Drug Delivery for Paranasal Sinuses: A Comprehensive Review |
Author: | Pourmehran, O. Zarei, K. Pourchez, J. Vreugde, S. Psaltis, A. Wormald, P.-J. |
Citation: | International Journal of Pharmaceutics, 2023; 644:123277-1-123277-18 |
Publisher: | Elsevier BV |
Issue Date: | 2023 |
ISSN: | 0378-5173 1873-3476 |
Statement of Responsibility: | Oveis Pourmehran, Kavan Zarei, Jeremie Pourchez, Sarah Vreugde, Alkis Psaltis, Peter-John Wormald |
Abstract: | Chronic rhinosinusitis (CRS) impacts patients' quality of life and healthcare costs. Traditional methods of drug delivery, such as nasal sprays and irrigation, have limited effectiveness. Acoustic Drug Delivery (ADD) using a nebulizer offers targeted delivery of drug to the sinuses, which may improve the treatment of CRS. This review examines the influence of aerosol particle characteristics, aero-acoustic parameters, inlet flow conditions, and acoustic waves on sinus drug delivery. Key findings reveal that smaller particles improve the ADD efficiency, whereas larger sizes or increased density impair it. The oscillation amplitude of the air plug in the ostium is crucial for the ADD efficiency. Introducing acoustic waves at the NC-sinus system's resonance frequency improves aerosol deposition within sinuses. Future research should address advanced models, optimizing particle characteristics, investigating novel acoustic waveforms, incorporating patient-specific anatomy, and evaluating long-term safety and efficacy. Tackling these challenges, ADD could offer more effective and targeted treatments for sinus-related conditions such as CRS. |
Keywords: | Acoustic Drug Delivery Chronic Rhinosinusitis Drug Delivery Nasal Cavity Paranasal Sinuses |
Description: | Available online 27 July 2023 |
Rights: | © 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
DOI: | 10.1016/j.ijpharm.2023.123277 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/2014977 |
Published version: | http://dx.doi.org/10.1016/j.ijpharm.2023.123277 |
Appears in Collections: | Surgery publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_139999.pdf | Published version | 13.36 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.