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https://hdl.handle.net/2440/140016
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Type: | Journal article |
Title: | Clinical predictors of rectal cancer response after neo-adjuvant (Chemo)Radiotherapy in Australia and New Zealand: Analysis of the Bi-National Colorectal Cancer Audit (BCCA) |
Author: | Liu, J. Lee, J.Y.T. Bedrikovetski, S. Traeger, L. Moore, J.W. Perry, J.L. Kroon, H.M. Sammour, T. |
Citation: | European Journal of Surgical Oncology, 2023; 49(11):107070-1-107070-5 |
Publisher: | Elsevier |
Issue Date: | 2023 |
ISSN: | 0748-7983 1532-2157 |
Statement of Responsibility: | Jianliang Liu, Justin Y.T. Lee, Sergei Bedrikovetski, Luke Traeger, James W. Moore, Joanne L. Perry, Hidde M. Kroon, Tarik Sammour |
Abstract: | Pathological complete response (pCR) is observed in 11–26% of locally advanced rectal cancers undergoing neoadjuvant chemoradiotherapy (nCRT). This study aims to determine pCR rates and clinicopathological predictors in the Australian and New Zealand (ANZ) cohort. The Bi-National Colorectal Cancer Audit (BCCA) was interrogated for all rectal cancer patients who underwent nCRT prior to surgical resection between 2007 and 2020. Patients were divided in two groups: pCR (AJCC tumour regression grade 0) and partial/no response (pPR, regression grade 1,2 or 3). In total, 3230 patients were included. Rates of pCR and pPR were 704 (21.8%) and 2526 (78.2%), respectively. Long-course nCRT (p < 0.0001), lower clinical tumour stage (cT; p < 0.0001), and nodal stage (cN; p = 0.003) were associated with pCR on univariate analysis. On multivariable analysis, cN0 stage and long-course nCRT remained independent factors for a pCR. Awareness of these predictors provides valuable information when counseling patients regarding prognosis and treatment options. |
Keywords: | Rectal cancer; Response; Tumour regression grade; Neoadjuvant therapy; Chemoradiotherapy |
Description: | Available online 9 September 2023 |
Rights: | Crown Copyright © 2023 Published by Elsevier Ltd. All rights reserved. |
DOI: | 10.1016/j.ejso.2023.107070 |
Published version: | https://www.sciencedirect.com/science/article/pii/S0748798323007084 |
Appears in Collections: | Surgery publications |
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