Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/140171
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease |
Author: | Barthelson, K. Newman, M. Lardelli, M. |
Citation: | Journal of Alzheimer's Disease Reports, 2020; 4(1):123-140 |
Publisher: | IOS Press |
Issue Date: | 2020 |
ISSN: | 2542-4823 2542-4823 |
Statement of Responsibility: | Karissa Barthelson, Morgan Newman and Michael Lardelli |
Abstract: | Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated with Alzheimer's disease (AD), the most common form of dementia. SORL1 is a unique gene in AD, as it appears to show strong associations with the common, late-onset, sporadic form of AD and the rare, early-onset familial form of AD. Here, we review the genetics of SORL1 in AD and discuss potential roles it could play in AD pathogenesis. |
Keywords: | Alzheimer’s disease amyloid amyloid-beta protein precursor endocytosis endosomes protein transport |
Rights: | © 2020 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0). |
DOI: | 10.3233/ADR-200177 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1061006 http://purl.org/au-research/grants/nhmrc/1045507 http://purl.org/au-research/grants/nhmrc/1061006 |
Published version: | http://dx.doi.org/10.3233/adr-200177 |
Appears in Collections: | Molecular and Biomedical Science publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_140171.pdf | Published version | 1.4 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.