Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/140495
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Type: | Journal article |
Title: | Asymmetric growth-limiting development of the female conceptus |
Author: | Estrella, C.A.S. Gatford, K.L. Xiang, R. Javadmanesh, A. Ghanipoor-Samami, M. Nattrass, G.S. Shuaib, E. McAllister, M.M. Beckman, I. Thomsen, D.A. Clifton, V.L. Owens, J.A. Roberts, C.T. Hiendleder, S. Kind, K.L. |
Citation: | Frontiers in Endocrinology, 2023; 14:1306513-1-1306513-14 |
Publisher: | Frontiers Media S.A. |
Issue Date: | 2023 |
ISSN: | 1664-2392 1664-2392 |
Statement of Responsibility: | Consuelo Amor S. Estrella, Kathryn L. Gatford, Ruidong Xiang, Ali Javadmanesh, Mani Ghanipoor-Samami, Greg S. Nattrass, Entesar Shuaib, Milton M. McAllister, Ian Beckman, Dana A. Thomsen, Vicki L. Clifton, Julie A. Owens, Claire T. Roberts, Stefan Hiendleder and Karen L. Kind |
Abstract: | Introduction: Sex differences in prenatal growth may contribute to sexdependent programming effects on postnatal phenotype. Methods: We integrated for the first time phenotypic, histomorphological, clinico-chemical, endocrine and gene expression analyses in a single species, the bovine conceptus at mid-gestation. Results: We demonstrate that by mid-gestation, before the onset of accelerated growth, the female conceptus displays asymmetric lower growth compared to males. Female fetuses were smaller with lower ponderal index and organ weights than males. However, their brain:body weight, brain:liver weight and heart:body weight ratios were higher than in males, indicating brain and heart ‘sparing’. The female placenta weighed less and had lower volumes of trophoblast and fetal connective tissue than the male placenta. Female umbilical cord vessel diameters were smaller, and female-specific relationships of body weight and brain:liver weight ratios with cord vessel diameters indicated that the umbilico-placental vascular system creates a growth-limiting environment where blood flow is redistributed to protect brain and heart growth. Clinico-chemical indicators of liver perfusion support this female-specific growth-limiting phenotype, while lower insulin-like growth factor 2 (IGF2) gene expression in brain and heart, and lower circulating IGF2, implicate female-specificmodulation of key endocrinemediators by nutrient supply. Conclusion: This mode of female development may increase resilience to environmental perturbations in utero and contribute to sex-bias in programming outcomes including susceptibility to non-communicable diseases. |
Keywords: | conceptus; uncomplicated pregnancy; sex differences; asymmetric growth; IGF system; histomorphology; clinico-chemical screen |
Description: | PUBLISHED 01 February 2024 |
Rights: | © 2024 Estrella, Gatford, Xiang, Javadmanesh, Ghanipoor-Samami, Nattrass, Shuaib, McAllister, Beckman, Thomsen, Clifton, Owens, Roberts, Hiendleder and Kind. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
DOI: | 10.3389/fendo.2023.1306513 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/GNT1020749 http://purl.org/au-research/grants/nhmrc/1041918 http://purl.org/au-research/grants/nhmrc/GNT1174971 |
Published version: | http://dx.doi.org/10.3389/fendo.2023.1306513 |
Appears in Collections: | Research Outputs |
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File | Description | Size | Format | |
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hdl_140495.pdf | Published version | 4.05 MB | Adobe PDF | View/Open |
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