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https://hdl.handle.net/2440/14328
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DC Field | Value | Language |
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dc.contributor.author | Knights, K. | - |
dc.contributor.author | McLean, C. | - |
dc.contributor.author | Tonkin, A. | - |
dc.contributor.author | Miners, J. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | British Journal of Clinical Pharmacology, 1995; 40(2):153-156 | - |
dc.identifier.issn | 0306-5251 | - |
dc.identifier.issn | 1365-2125 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14328 | - |
dc.description.abstract | The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion. | - |
dc.description.statementofresponsibility | Knights, Km ; Mclean, Cf ; Tonkin, Al ; Miners, Jo | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Scientific | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-2125.1995.tb05769.x | - |
dc.subject | Humans | - |
dc.subject | Ibuprofen | - |
dc.subject | Contraceptives, Oral, Hormonal | - |
dc.subject | Anti-Inflammatory Agents, Non-Steroidal | - |
dc.subject | Administration, Oral | - |
dc.subject | Analysis of Variance | - |
dc.subject | Sex Factors | - |
dc.subject | Stereoisomerism | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-2125.1995.tb05769.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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