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https://hdl.handle.net/2440/14338
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dc.contributor.author | Coller, J. | - |
dc.contributor.author | Somogyi, A. | - |
dc.contributor.author | Bochner, F. | - |
dc.date.issued | 1997 | - |
dc.identifier.citation | British Journal of Clinical Pharmacology, 1997; 43(6):659-660 | - |
dc.identifier.issn | 0306-5251 | - |
dc.identifier.issn | 1365-2125 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14338 | - |
dc.description.abstract | <h4>Aims</h4>To examine the relationship between proguanil metabolism and the number of mutations in CYP2C19 by comparing the CYP2C19 genotype and proguanil phenotype of 10 subjects.<h4>Methods</h4>Partial clearance and urinary metabolic ratio data were obtained from a previous study of 10 subjects [5]. Analysis of CYP2C19 genotypes was performed using PCR amplification followed by restriction endonuclease digestion of genomic DNA from a blood sample.<h4>Results</h4>The intrinsic partial clearance of PG to CG ranged from 0.41-10.11 h-1, and was related to the number of functional CYP2C19 alleles present. Genotypic PMs had metabolic ratios > 13, while genotypic heterozygote EMs had metabolic ratios < 9.<h4>Conclusions</h4>Proguanil may be a suitable phenotyping probe for the CYP2C19 genetic polymorphism, however the exact antimode of the urinary metabolic ratio chosen to separate poor and extensive metabolisers needs further investigation. | - |
dc.language.iso | en | - |
dc.publisher | BLACKWELL SCIENCE LTD | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1365-2125.1997.00596.x | - |
dc.subject | Humans | - |
dc.subject | Cytochrome P-450 Enzyme System | - |
dc.subject | Aryl Hydrocarbon Hydroxylases | - |
dc.subject | DNA Restriction Enzymes | - |
dc.subject | Mixed Function Oxygenases | - |
dc.subject | DNA | - |
dc.subject | Antimetabolites | - |
dc.subject | Administration, Oral | - |
dc.subject | Polymerase Chain Reaction | - |
dc.subject | Gene Expression Regulation, Enzymologic | - |
dc.subject | Genotype | - |
dc.subject | Heterozygote | - |
dc.subject | Phenotype | - |
dc.subject | Polymorphism, Genetic | - |
dc.subject | Alleles | - |
dc.subject | Proguanil | - |
dc.subject | Cytochrome P-450 CYP2C19 | - |
dc.subject | Asian People | - |
dc.subject | White People | - |
dc.title | Association between CYP2C19 genotype and proguanil oxidative polymorphism. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1365-2125.1997.00596.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Coller, J. [0000-0002-8273-5048] | - |
dc.identifier.orcid | Somogyi, A. [0000-0003-4779-0380] | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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