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https://hdl.handle.net/2440/14437
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dc.contributor.author | Chew, M. | - |
dc.contributor.author | White, J. | - |
dc.contributor.author | Somogyi, A. | - |
dc.contributor.author | Bochner, F. | - |
dc.contributor.author | Irvine, R. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | European Journal of Pharmacology, 2001; 425(3):159-164 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14437 | - |
dc.description | Copyright © 2001 Elsevier Science B.V. All rights reserved. | - |
dc.description.abstract | The role of metabolic polymorphism in the development of physical dependence to codeine was assessed in cytochrome P450 2D2 (CYP2D2) deficient Dark Agouti and CYP2D2 intact Sprague-Dawley rats by assessment of the severity of naloxone precipitated withdrawal after codeine and morphine administration. Plasma morphine concentrations after codeine were significantly higher (P<0.01) in Sprague-Dawley than in Dark Agouti rats with metabolic ratios of 0.71±0.27 and 0.07±0.04, respectively. Withdrawal after codeine resulted in significantly greater hypothermia (3.5–4 °C, P<0.0001) in Sprague-Dawley animals compared to the other groups. Body weight loss was similar for all groups ranging from 6.2±0.4 to 8.2±0.6 g. When strain and treatment data were combined, a relationship between body temperature and plasma morphine concentration could be described by the inverse Hill equation (r2=0.76, EC50=556±121 ng/ml, n=2.9±1.5). These data indicate that dependence and withdrawal after codeine administration are dependent on its bioconversion to morphine. | - |
dc.description.statementofresponsibility | May Chew, Jason M. White, Andrew A. Somogyi, Felix Bochner and Rodney J. Irvine | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/506087/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science BV | - |
dc.source.uri | http://dx.doi.org/10.1016/s0014-2999(01)01185-2 | - |
dc.subject | Codeine | - |
dc.subject | Morphine | - |
dc.subject | CYP2D2 | - |
dc.subject | opioid dependence | - |
dc.subject | opioid withdrawal | - |
dc.title | Precipitated withdrawal following codeine administration is dependent on CYP genotype | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0014-2999(01)01185-2 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Somogyi, A. [0000-0003-4779-0380] | - |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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