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https://hdl.handle.net/2440/14441
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dc.contributor.author | McLennan, P. | - |
dc.contributor.author | Howe, P. | - |
dc.contributor.author | Abeywardena, M. | - |
dc.contributor.author | Muggli, R. | - |
dc.contributor.author | Raederstorff, D. | - |
dc.contributor.author | Mano, M. | - |
dc.contributor.author | Rayner, T. | - |
dc.contributor.author | Head, R. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | European Journal of Pharmacology, 1996; 300(1-2):83-89 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14441 | - |
dc.description.abstract | Dietary fish oils rich in n-3 polyunsaturated fatty acids can modulate a diverse range of factors contributing to cardiovascular disease. This study examined the relative roles of eicosapentaenoic acid (20:5 n-3; EPA) and docosahexaenoic acid (22:6 n-3; DHA) which are the principal n-3 polyunsaturated fatty acids regarded as candidates for cardioprotective actions. At low dietary intakes (0.4–1.1% of energy (%en)), docosahexaenoic acid but not eicosapentaenoic acid inhibited ischaemia-induced cardiac arrhythmias. At intakes of 3.9–10.0%en, docosahexaenoic acid was more effective than eicosapentaenoic acid at retarding hypertension development in spontaneously hypertensive rats (SHR) and inhibiting thromboxane-like vasoconstrictor responses in aortas from SHR. In stroke-prone SHR with established hypertension, docosahexaenoic acid (3.9–10.0%en) retarded the development of salt-loading induced proteinuria but eicosapentaenoic acid alone was ineffective. The results demonstrate that purified n-3 polyunsaturated fatty acids mimic the cardiovascular actions of fish oils and imply that docosahexaenoic acid may be the principal active component conferring cardiovascular protection. | - |
dc.description.statementofresponsibility | Peter McLennan, Peter Howe, Mahinda Abeywardena, Reto Muggli, Daniel Raederstorff, Mark Mano, Tim Rayner and Richard Head | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | © 1996 Elsevier Science B.V | - |
dc.source.uri | http://www.sciencedirect.com.proxy.library.adelaide.edu.au/science/article/pii/0014299995008616# | - |
dc.subject | Dietary fat | - |
dc.subject | n-3 fatty acid | - |
dc.subject | Arrhythmia | - |
dc.subject | Blood pressure | - |
dc.subject | Proteinuria | - |
dc.subject | Thromboxane | - |
dc.title | The cardiovascular protective role of docosahexaenoic acid. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/0014-2999(95)00861-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Howe, P. [0000-0001-6546-7742] | - |
dc.identifier.orcid | Head, R. [0000-0002-1196-0926] | - |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
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