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https://hdl.handle.net/2440/14539
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Type: | Journal article |
Title: | Evaluation of the intestinal absorption of erythromycin in man: Absolute bioavailability and comparison with enteric coated erythromycin |
Author: | Somogyi, A. Bochner, F. Hetzel, D. Williams, D. |
Citation: | Pharmaceutical Research, 1995; 12(1):149-154 |
Publisher: | PLENUM PUBL CORP |
Issue Date: | 1995 |
ISSN: | 0724-8741 1573-904X |
Abstract: | To determine the role of acid hydrolysis on the gastrointestinal absorption of erythromycin, six healthy subjects received erythromycin as a 240 mg intravenous dose, a 250 mg oral solution administered via endoscope directly into the duodenum and bypassing the stomach, and an enteric-coated 250 mg capsule. Blood samples were collected for 6 hours and serum erythromycin quantified by a microbiological method. The time to achieve maximum serum concentrations for the solution was 0.25 +/- 0.08 (mean +/- SD) hours and for the capsule was 2.92 +/- 0.55 hours. The absolute bioavailability of erythromycin from the capsule was 32 +/- 7% and for the duodenal solution 43 +/- 14%. The ratio of the areas under the serum erythromycin concentration-time curve of capsule to solution was 80 +/- 28% (range 38 to 110%). There is substantial loss of erythromycin apart from gastric acid hydrolysis, which cannot be accounted for by hepatic first-pass metabolism. Attempts to further improve the oral bioavailability of erythromycin beyond 50% by manipulation of formulation are likely to be futile. |
Keywords: | Duodenum Humans Erythromycin Capsules Solutions Drug Administration Routes Administration, Oral Injections, Intravenous Biological Availability Intestinal Absorption Chemistry, Pharmaceutical Adult Female Male Evaluation Studies as Topic |
DOI: | 10.1023/A:1016215510223 |
Published version: | http://dx.doi.org/10.1023/a:1016215510223 |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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