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https://hdl.handle.net/2440/14546
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Type: | Journal article |
Title: | The effects of central and peripheral angiotensin on hypertension and nociception in rats |
Author: | Irvine, R. White, J. |
Citation: | Pharmacology, Biochemistry and Behavior, 1997; 57(1):37-41 |
Publisher: | Elsevier BV |
Issue Date: | 1997 |
ISSN: | 0091-3057 1873-5177 |
Abstract: | Spontaneously hypertensive rats (SHRs) rats have been reported to have decreased sensitivity to pain, but as yet a mechanism has not been identified. This study investigated the effects of subcutaneous and intracerebroventricular (ICV) infusions of angiotensin II on blood pressure, locomotor activity, and tailflick and hot plate latencies in the Wistar-Kyoto (WKY) and outbred Wistar rat. Peripheral but not central administration of angiotensin II (567 micrograms/kg/day) increased hot plate latencies in WKY and Wistar rats to a level equivalent to that observed in the SHR. Peripheral administration of norepinephrine (50 and 100 mg/kg/day) to WKYs increased blood pressure but had no effect on hotplate latency. ICV administration of losartan (1 & 3 mg/kg/day) to SHRs had no effect on blood pressure or nociception. The results indicate that angiotensin II has a role in the altered pain perception observed in the SHR and that its site of action is peripheral. |
Keywords: | Cerebral Ventricles Animals Rats, Inbred SHR Rats, Inbred WKY Rats Rats, Wistar Pain Hypertension Biphenyl Compounds Losartan Tetrazoles Imidazoles Angiotensin II Analgesics Antihypertensive Agents Analysis of Variance Infusion Pumps, Implantable Reaction Time Male |
DOI: | 10.1016/S0091-3057(96)00166-9 |
Published version: | http://dx.doi.org/10.1016/s0091-3057(96)00166-9 |
Appears in Collections: | Aurora harvest 2 Pharmacology publications |
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