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https://hdl.handle.net/2440/14740
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dc.contributor.author | Ong, J. | - |
dc.contributor.author | Kerr, D. | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Canadian Journal of Physiology and Pharmacology, 2000; 78(6):507-511 | - |
dc.identifier.issn | 0008-4212 | - |
dc.identifier.issn | 1205-7541 | - |
dc.identifier.uri | http://hdl.handle.net/2440/14740 | - |
dc.description.abstract | In rat neocortical slices maintained in Mg2+-free Kreb's medium, the effects of Ca2+ concentration on repetitive spontaneous discharges and on GABA(B) receptor-mediated responses were investigated. Over a concentration range of 0.3-2.4 mM Ca2+, there was a reduction of discharge amplitude, with a 50 +/- 6.5% reduction in 0.3 mM Ca2+, whilst the burst frequency remained unaffected. Baclofen, the GABA(B) receptor agonist, produced a concentration-dependent depression of discharge frequency, reversibly antagonised by the antagonist (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (Sch 50911). The EC50 value for baclofen in 2.4 mM Ca2+ was 11 microM, while the EC50 values in 0.3, 0.6, 1.2, and 1.8 mM Ca2+ were 1.3, 2.5, 3.6, and 10 microM, respectively, resulting in 8.5, 4.4, 3.1, and 1.1-fold leftward shifts. This enhanced action of baclofen in low extracellular Ca2+ concentrations in the neocortex may be the result of a lower concentration gradient which reinforces the action of baclofen. | - |
dc.language.iso | en | - |
dc.publisher | Natl Research Council Canada | - |
dc.subject | Neocortex | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Calcium Chloride | - |
dc.subject | Baclofen | - |
dc.subject | Receptors, GABA-B | - |
dc.subject | GABA Agonists | - |
dc.subject | Synaptic Transmission | - |
dc.subject | Male | - |
dc.title | Effects of Ca2+ concentration on GABAB receptor function in rat neocortical slices | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1139/y00-017 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 2 |
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