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https://hdl.handle.net/2440/14751
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Type: | Journal article |
Title: | A xylazine infusion regimen to provide analgesia in sheep |
Author: | Grant, C. Summersides, G. Kuchel, T. |
Citation: | Laboratory Animals, 2001; 35(3):277-281 |
Publisher: | Royal Soc Medicine Press Ltd |
Issue Date: | 2001 |
ISSN: | 0023-6772 1758-1117 |
Abstract: | The efficacy of continuous low-dose xylazine infusion following an initial loading dose in providing analgesia in sheep was examined using an algesimetry method based on a leg lifting response to an electrical stimulus. Sheep received a 5 mg intramuscular injection of xylazine followed by continuous infusion of intravenous xylazine (2 mg/h) for 90 min. This treatment resulted in significant increases in the level of current required to elicit a leg lifting response (287% of baseline) and steady state analgesia was maintained from 10 min after the start of the infusion until the end of the experimental period. This protocol appears to be a simple and effective regimen for providing steady state analgesia in sheep. |
Keywords: | Animals Sheep Xylazine Adrenergic alpha-Agonists Analgesia Injections, Intramuscular Male |
DOI: | 10.1258/0023677011911606 |
Published version: | http://dx.doi.org/10.1258/0023677011911606 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 7 |
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