Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/16641
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Fungal-specific humoral response in eosinophilic mucus chronic rhinosinusitis |
Author: | Pant, H. Kette, F. Smith, W. Wormald, P. Macardle, P. |
Citation: | The Laryngoscope, 2005; 115(4):601-606 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2005 |
ISSN: | 0023-852X 1531-4995 |
Statement of Responsibility: | Pant, Harshita ; Kette, Frank E. ; Smith, William B. ; Wormald, Peter J. ; Macardle, Peter J. |
Abstract: | <h4>Objectives/hypothesis</h4>An immunoglobulin (Ig)E-mediated allergic pathogenesis is presumed in allergic fungal sinusitis (AFS), yet extensive polyps and eosinophilic mucus (EM) in the paranasal sinuses may also occur in the absence of allergy. Although a noninvasive fungal pathogenesis is presumed in all chronic rhinosinusitis with EM (EMCRS), fungal-specific nonallergic immune responses have not been thoroughly investigated. We tested the hypothesis that there is a fungal-specific humoral response in EMCRS and that it is not confined to IgE.<h4>Study design</h4>EMCRS patients were prospectively stratified into subgroups based on the presence or absence of fungi within EM and of fungal-specific systemic IgE. There were 12 AFS, 5 AFS-like, 8 nonallergic fungal eosinophilic sinusitis (NAFES), and 5 nonallergic, nonfungal eosinophilic sinusitis (NANFES) patients.<h4>Methods</h4>Alternaria alternata and Aspergillus fumigatus-specific serum IgE, IgG, IgM, and IgA was measured by enzyme-linked immunosorbent assay and compared with strictly defined healthy and disease-control groups.<h4>Results</h4>Fungal-specific IgG (Alternaria alternata P = .0002; Aspergillus fumigatus P = .004), and IgA levels (Alternaria alternata P = .0016; Aspergillus fumigatus P = .002) were higher in EMCRS compared with healthy volunteers but not with disease controls. Fungal-specific IgG3 levels were significantly elevated in all the EMCRS subgroups compared with controls for either fungal antigen (P < .0001). Importantly, fungal-specific IgE levels were not significantly different between fungal-allergic EMCRS and disease controls.<h4>Conclusions</h4>Fungal-specific immunity characterized by serum IgG3 and not IgE, distinguished the EMCRS subgroups from control groups regardless of the presence of fungus within EM or of systemic fungal allergy. Fungal-specific IgE responses in fungal-allergic EMCRS were no different to those in fungal-allergic controls, thus challenging the presumption of a unique pathogenic role of fungal allergy in "allergic fungal sinusitis." |
Keywords: | Allergic fungal sinusitis mucin IgE pathophysiology eosinophilic eosinophilic mucin rhinosinusitis |
Rights: | © 2005 The Triological Society |
DOI: | 10.1097/01.mlg.0000161341.00258.54 |
Published version: | http://dx.doi.org/10.1097/01.mlg.0000161341.00258.54 |
Appears in Collections: | Aurora harvest 6 Surgery publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.