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https://hdl.handle.net/2440/16859
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DC Field | Value | Language |
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dc.contributor.author | Anderson, K. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | The Economic Record, 2005; 81(255):414-438 | - |
dc.identifier.issn | 0013-0249 | - |
dc.identifier.issn | 1475-4932 | - |
dc.identifier.uri | http://hdl.handle.net/2440/16859 | - |
dc.description | An earlier version was circulated as CEPR Discussion Paper No. 4592, London, September 2004 and as World Bank Policy Research Working Paper 3415, Washington DC, September 2004. | - |
dc.description.abstract | Allografts used in the repair of congenital heart defects in children induce a persistent broad HLA antibody response. We have previously shown that a 3-month course of mycophenolic mofetil (MMF) significantly reduces the HLA class I antibody response to valved allograft implantation in children. The purpose of this study was to determine if this reduction in HLA antibody persists after discontinuation of MMF. We conducted follow-up (mean 2 +/- 0.5 years) of seven patients who had received allograft placement for repair of congenital heart defects. These patients received 3 months of immunosuppression with MMF following allograft implantation. When compared to historical controls, patients who received MMF following surgery showed a significantly decreased HLA class I antibody response at 2 years postimplantation. This study demonstrates the ability to persistently alter the HLA class I antibody response using 3 months of MMF following allograft implantation in children. | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Asia | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1475-4932.2005.00279.x | - |
dc.subject | Heart Valves | - |
dc.subject | Humans | - |
dc.subject | Heart Defects, Congenital | - |
dc.subject | Mycophenolic Acid | - |
dc.subject | Immunosuppressive Agents | - |
dc.subject | Antibodies | - |
dc.subject | Histocompatibility Antigens Class I | - |
dc.subject | Histocompatibility Antigens Class II | - |
dc.subject | HLA Antigens | - |
dc.subject | Fluorescent Antibody Technique, Indirect | - |
dc.subject | Histocompatibility Testing | - |
dc.subject | Flow Cytometry | - |
dc.subject | Sensitivity and Specificity | - |
dc.subject | Pilot Projects | - |
dc.subject | Immunologic Techniques | - |
dc.subject | Antibody Formation | - |
dc.subject | Graft Rejection | - |
dc.subject | Time Factors | - |
dc.subject | Adolescent | - |
dc.subject | Child | - |
dc.subject | Child, Preschool | - |
dc.subject | Infant | - |
dc.subject | Infant, Newborn | - |
dc.title | On the virtues of multilateral trade negotiations | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1475-4932.2005.00279.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Anderson, K. [0000-0002-1472-3352] | - |
Appears in Collections: | Aurora harvest 2 Economics publications |
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