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https://hdl.handle.net/2440/17237
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Type: | Journal article |
Title: | Pre-eclampsia |
Author: | Sibai, B. Dekker, G. Kupferminc, M. |
Citation: | The Lancet, 2005; 365(9461):785-799 |
Publisher: | Lancet Ltd |
Issue Date: | 2005 |
ISSN: | 0140-6736 1474-547X |
Statement of Responsibility: | Baha Sibai, Gus Dekker, and Michael Kupferminc |
Abstract: | Pre-eclampsia is a major cause of maternal mortality (15–20% in developed countries) and morbidities (acute and long-term), perinatal deaths, preterm birth, and intrauterine growth restriction. Key findings support a causal or pathogenetic model of superficial placentation driven by immune maladaptation, with subsequently reduced concentrations of angiogenic growth factors and increased placental debris in the maternal circulation resulting in a (mainly hypertensive) maternal inflammatory response. The final phenotype, maternal pre-eclamptic syndrome, is further modulated by pre-existing maternal cardiovascular or metabolic fitness. Currently, women at risk are identified on the basis of epidemiological and clinical risk factors, but the diagnostic criteria of pre-eclampsia remain unclear, with no known biomarkers. Treatment is still prenatal care, timely diagnosis, proper management, and timely delivery. Many interventions to lengthen pregnancy (eg, treatment for mild hypertension, plasma-volume expansion, and corticosteroid use) have a poor evidence base. We review findings on the diagnosis, risk factors, and pathogenesis of pre-eclampsia and the present status of its prediction, prevention, and management. |
Keywords: | Humans Pre-Eclampsia Pregnancy Outcome Pregnancy Female |
DOI: | 10.1016/S0140-6736(05)17987-2 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/31066/description#description |
Published version: | http://dx.doi.org/10.1016/s0140-6736(05)71003-5 |
Appears in Collections: | Aurora harvest 6 Obstetrics and Gynaecology publications |
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