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https://hdl.handle.net/2440/17303
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Type: | Journal article |
Title: | TNF-receptor levels in preeclampsia - results of a longitudinal study in high-risk women |
Author: | Schipper, E. Bolte, A. Schalkwijk, C. van Geijn, G. Dekker, G. |
Citation: | The Journal of Maternal-Fetal and Neonatal Medicine, 2005; 18(5):283-287 |
Publisher: | Taylor & Francis Ltd |
Issue Date: | 2005 |
ISSN: | 1476-7058 1476-4954 |
Statement of Responsibility: | Elbert-Jaap I. Schipper, Antoinette C. Bolte, Casper G. Schalkwijk, Herman P. Van Geijn, and Gustaaf A. Dekker |
Abstract: | Objective. Tumor necrosis factor-alpha (TNF-) is thought to play a role in immune activation in preeclampsia. The objective of this study was to establish if soluble TNF-receptor I (sTNF-rI) levels relate to the onset and severity of preeclampsia. Methods. Maternal plasma sTNF-rI levels were studied throughout pregnancy in 68 women with a history of severe preeclampsia or intra-uterine growth restriction (IUGR), and primigravidas with chronic hypertension. Data are presented as mean (SD) in ng/ml. Results. In the second trimester there was a significant difference in sTNF-rI levels between preeclamptic pregnancies with and without IUGR (means 1.33 (0.20) and 1.11 (0.15) respectively, p < 0.005). In severe preeclampsia with delivery before 34 weeks of gestation, sTNF-rI levels were higher than in mild preeclampsia in the second and third trimesters (means 1.40 (0.16) vs. 1.16 (0.19), p < 0.02 and 1.82 (0.47) vs. 1.42 (0.22), p < 0.05, respectively). Conclusion. sTNF-rI levels were higher in preeclampsia with fetal involvement, suggesting that increased TNF- production in preeclampsia is related to impaired placentation rather than to the maternal syndrome. |
Keywords: | Preeclampsia tumor necrosis factor fetal growth restriction |
Description: | © 2008 Informa plc |
DOI: | 10.1080/14767050500246466 |
Description (link): | http://www.informaworld.com/smpp/content?content=10.1080/14767050500246466 |
Published version: | http://dx.doi.org/10.1080/14767050500246466 |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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