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https://hdl.handle.net/2440/17403
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Type: | Journal article |
Title: | Expression of toll-like receptors on B lymphocytes |
Author: | Dasari, P. Nicholson, I. Hodge, G. Dandie, G. Zola, H. |
Citation: | Cellular Immunology, 2005; 236(1-2):140-145 |
Publisher: | Academic Press Inc |
Issue Date: | 2005 |
ISSN: | 0008-8749 1090-2163 |
Abstract: | Toll-like receptors (TLRs) are a family of trans-membrane receptors that play an important role in the innate immune system. Most studies examining the cellular expression of TLRs on immune cells have focussed on neutrophils, monocytes and dendritic cells, but there is little evidence of TLRs being expressed on lymphocytes. Using 3-colour flow cytometry, expression of TLR-1, TLR-2, TLR-3, TLR-4, and TLR-9 on peripheral blood lymphocyte populations was determined. Further examination of TLRs on CD5- and CD5+ CD19+ B cell subsets was performed. The binding of TLR1 and TLR9 antibodies was detected on 15-90% of resting B cells, but not on resting T-cells. The higher expression of TLR1 and TLR9 on CD5+ B cells compared to CD5- B cells may reflect the role of B1 cells in more primitive, less specific antibody responses. |
Keywords: | B-Lymphocytes B-Lymphocyte Subsets Leukocytes, Mononuclear Humans Antigens, CD5 Antigens, CD19 Antibodies, Monoclonal Flow Cytometry Toll-Like Receptors |
DOI: | 10.1016/j.cellimm.2005.08.020 |
Published version: | http://dx.doi.org/10.1016/j.cellimm.2005.08.020 |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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