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https://hdl.handle.net/2440/17405
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Type: | Journal article |
Title: | A comparison of Verotoxin B-subunit (Stx1B) and CD77 antibody to define germinal centre populations |
Author: | Bailey, S. Mardell, C. Wheatland, L. Zola, H. Macardle, P. |
Citation: | Cellular Immunology, 2005; 236(1-2):167-170 |
Publisher: | Academic Press Inc |
Issue Date: | 2005 |
ISSN: | 0008-8749 1090-2163 |
Statement of Responsibility: | S. Bailey, C. Mardell, L. Wheatland, H. Zola, P. J. Macardle |
Abstract: | We have directly compared the use of a CD77 antibody with the binding subunit of Shiga-like toxin 1, Verotoxin 1, and (Stx1B) for delineation on human tonsil cells. We determined that the Stx1B produced a greater intensity of staining than the CD77 antibody, allowing three sub-populations of germinal centre cells to be seen. The populations express high, medium, and low levels of globotriaosylceramide as determined by the binding of the Stx1B reagent. The strong staining patterns of Stx1B suggest that it may be useful in defining germinal center B cell populations. |
Keywords: | CD77 Shiga-like toxin Germinal centre B-lymphocytes Flow cytometry |
Rights: | © 2005 Elsevier Inc. All rights reserved |
DOI: | 10.1016/j.cellimm.2005.08.023 |
Published version: | http://dx.doi.org/10.1016/j.cellimm.2005.08.023 |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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