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https://hdl.handle.net/2440/19507
Type: | Thesis |
Title: | Lymphocyte expression of costimulator molecules in early life / Salenna R. Elliott. |
Author: | Elliott, Salenna R. |
Issue Date: | 1999 |
School/Discipline: | Dept. of Paediatrics |
Abstract: | In T-dependent antibody responses, costimulator molecules provide contact-medited signals during interactions between T cells and B cells that regulate lymphocyte activation. This study investigated the hypothesis that costimulator molecules are differentially expressed on lymphocytes from neonates and young children compared with adults, contributing to limitations of T-dependent antibody responses in early life. Results suggest that lymphocytes from young children should be able to deliver and respond to costimulatory signals. The differences in lymphocyte expression of these costimulator molecules in young children are unlikely to fully account for limitations in humoral immunity in early life, and may even represent a specialised adaptation for this stage of immune development. |
Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Paediatrics, 2000 |
Subject: | Lymphocytes Immunological aspects. |
Description: | Bibliography: leaves 170-206. vi, 206 leaves : ill. (some col.) ; 30 cm. |
Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text. |
Appears in Collections: | Research Theses |
Files in This Item:
File | Description | Size | Format | |
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01front.pdf | 117.29 kB | Adobe PDF | View/Open | |
02whole.pdf | 10.8 MB | Adobe PDF | View/Open | |
Permissions Restricted Access | Library staff access only | 589.67 kB | Adobe PDF | View/Open |
Restricted Restricted Access | Library staff access only | 14.45 MB | Adobe PDF | View/Open |
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