Cellular and molecular mechanisms by which the insert negative isoform of the human calcitonin receptor regulates cell growth / by Liza-Jane Raggatt.

Abstract

Calcitonin (CT) is a 32 amino acid peptide hormone, known to inhibit osteoclastic bone resorption by direct interaction with cell surface calcitonin receptors (CTR). This study aims to define the intracellular mechanisms by which CT treatment results in decreased cellular proliferation. Results show, for the first time, that the growth regulating actions of CT are receptor isoform specific. In addition, CT inhibition of cellular proliferation occurs by arresting cells in the G2 phase of the cell cycle via a p21 mediated mechanism, which is at least partially activated through the Erk1/2 Map Kinase pathway.