Adelaide Research & Scholarship
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https://hdl.handle.net/2440/21724
| Type: | Thesis |
| Title: | Mechanisms of apoptosis of colorectal cancer cells by butyrate and other preventive agents / by Fugui Chai. |
| Author: | Chai, Fugui |
| Issue Date: | 2001 |
| School/Discipline: | Dept. of Medicine |
| Abstract: | The main aims of this study were firstly, to study the mechanism by which butyrate (the main fermentation product of dietary fibre) induces apoptosis of CRC cells, and secondly, to determine the effect of butyrate in combination with NSAIDs (chemopreventive agents) and other agents on apoptosis of CRC cells. For these studies LIM1215 cells and, in some experiments, SW480 cells were used. The experiments described in this thesis provided new data on the caspase-3 activation and apoptosis in butyrate-induced apoptosis of CRC cells, and the interaction of these processes with a number of cellular factors and pharmacological agents. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 2001 |
| Description: | Bibliography: leaves 168-201. xx, 202, [37] leaves, [91] leaves of plates : ill. (some col.) ; 30cm. |
| Provenance: | Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text. This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 575.53 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 15.3 MB | Adobe PDF | View/Open | |
| Permissions Restricted Access | Library staff access only | 550.49 kB | Adobe PDF | View/Open |
| Restricted Restricted Access | Library staff access only | 18.51 MB | Adobe PDF | View/Open |
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