Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies / Suzanne M. Froscio.

Froscio, Suzanne Marie

Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/21753

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DC Field	Value	Language
dc.contributor.author	Froscio, Suzanne Marie	en
dc.date.issued	2002	en
dc.identifier.uri	http://hdl.handle.net/2440/21753	-
dc.description	Copy of author's previously published work inserted.	en
dc.description	Bibliography: leaves 121-139.	en
dc.description	xvii, 139 leaves : ill. (some col.) ; 30 cm.	en
dc.description.abstract	The aim of this study was to determine the extent to which protein synthesis inhibition, lowered glutathione (GSH) levels and toxin metabolism contribute to the toxicity of cyclindrospermopsin. Both hepatocyte cultures and reticulocyte lysates were utilized as in vitro tools of investigation. The findings imply that the inhibition of protein synthesis by direct action of the toxin cannot be considered a primary cause of hepatocyte cell death over an acute time frame. Cytochrome P450-derived metabolites may play a crucial role in cytotoxicity, and the toxicity process does not appear to involve oxidative damage.	en
dc.format.extent	267637 bytes	en
dc.format.mimetype	application/pdf	en
dc.language.iso	en	en
dc.title	Investigation of the mechanisms involved in cylindrospermopsin toxicity : hepatocyte culture and reticulocyte lysate studies / Suzanne M. Froscio.	en
dc.type	Thesis	en
dc.contributor.school	Dept. of Clinical and Experimental Pharmacology	en
dc.provenance	This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals. Copyright material removed from digital thesis. See print copy in University of Adelaide Library for full text.	en
dc.description.dissertation	Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 2002?	en
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