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https://hdl.handle.net/2440/23126
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Type: | Journal article |
Title: | Prenatal zinc treatment at the time of acute ethanol exposure limits spatial memory impairments in mouse offspring |
Author: | Pearce, B. Rofe, A. Coyle, P. |
Citation: | Pediatric Research, 2006; 59(1):66-71 |
Publisher: | Int Pediatric Research Foundation Inc |
Issue Date: | 2006 |
ISSN: | 0031-3998 1530-0447 |
Statement of Responsibility: | Brooke L. Summers, Allan M. Rofe and Peter Coyle |
Abstract: | Zinc (Zn) treatment given together with acute ethanol in early pregnancy has previously been demonstrated to protect against physical birth abnormalities in mice. The current study examined whether this Zn treatment (s.c. injection) can also prevent the more subtle cognitive impairments caused by ethanol exposure in early pregnancy. Pregnant C57BL/6J dams were injected with saline (0.85% wt/vol NaCl) or 25% ethanol (0.015 mL/g body weight) intraperitoneally at 0 and 4 h on gestational d (GD) 8. ZnSO4 (2.5 μg Zn/g at 0 h) treatment was administered by s.c. injection immediately following ethanol treatment. Offspring were randomly selected from litters for each of the three treatment groups and were tested at 55 and 70 d of age using a cross-maze water escape task for spatial learning and memory impairments consecutively. No differences were observed between treatments for the spatial learning task. However, young adult mice exposed to ethanol in utero demonstrated impaired spatial memory, with a decrease in correct trials and increased escape latency and incorrect entry measurements, compared with saline-treated controls. In comparison, offspring given s.c. Zn treatment at the time of ethanol exposure were not cognitively impaired, performing at the same level as control mice in the cross-maze escape task. These findings indicate that critically timed Zn administration can limit spatial memory impairments caused by ethanol exposure in early pregnancy. |
Keywords: | Animals Mice, Inbred C57BL Mice Memory Disorders Body Weight Zinc Ethanol Prenatal Care Learning Space Perception Pregnancy Litter Size Female Fetal Alcohol Spectrum Disorders |
Rights: | Copyright © 2005 International Pediatric Research Foundation |
DOI: | 10.1203/01.pdr.0000190573.23893.13 |
Published version: | http://dx.doi.org/10.1203/01.pdr.0000190573.23893.13 |
Appears in Collections: | Aurora harvest 2 Pathology publications |
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