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https://hdl.handle.net/2440/23138
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dc.contributor.author | Ashwood, P. | - |
dc.contributor.author | Crowther, C. | - |
dc.contributor.author | Willson, K. | - |
dc.contributor.author | Haslam, R. | - |
dc.contributor.author | Kennaway, D. | - |
dc.contributor.author | Hiller, J. | - |
dc.contributor.author | Robinson, J. | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | American Journal of Obstetrics and Gynecology, 2006; 194(3):861-867 | - |
dc.identifier.issn | 0002-9378 | - |
dc.identifier.issn | 1097-6868 | - |
dc.identifier.uri | http://hdl.handle.net/2440/23138 | - |
dc.description | Copyright © 2006 Mosby, Inc. All rights reserved. | - |
dc.description.abstract | <h4>Objective</h4>Do repeat prenatal corticosteroids suppress neonatal cortisol concentrations?<h4>Study design</h4>Randomized controlled trial of women given weekly repeat corticosteroids or saline placebo, while at risk of preterm birth, until 32 weeks' gestation.<h4>Results</h4>Cord serum cortisol concentrations in infants exposed to repeat corticosteroids were similar compared with infants exposed to a single course of corticosteroids (mean difference -26 nmol/L (95% CI -57, 5 nmol/L, P = .10), as were prestress salivary cortisol concentrations on day 3 (median 16.5 vs 15.3 nmol/L, P = .96). The adrenal response to a stressor on day 3 was lower in the repeat corticosteroid group compared with the single course group (median 11.9 vs 21.4 nmol/L, P = .02). Cortisol concentrations were lower in the repeat corticosteroid group on day 7 (median 11.7 vs 18.2 nmol/L, P = .04), but not on days 14 and 21.<h4>Conclusion</h4>The short- or long-term clinical impact, if any, of these changes in adrenal function needs to be determined. | - |
dc.description.statementofresponsibility | Patricia J. Ashwood; Caroline A. Crowther; Kristyn J. Willson; Ross R. Haslam; David J. Kennaway; Janet E. Hiller; and Jeffrey S. Robinson | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/623277/description#description | - |
dc.language.iso | en | - |
dc.publisher | Mosby Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.ajog.2005.08.063 | - |
dc.subject | Repeat corticosteroids | - |
dc.subject | Neonatal adrenal suppression | - |
dc.subject | Randomized trial | - |
dc.title | Neonatal adrenal function after repeat dose prenatal corticosteroids: A randomized controlled trial | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.ajog.2005.08.063 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ashwood, P. [0000-0003-4654-3281] | - |
dc.identifier.orcid | Crowther, C. [0000-0002-9079-4451] | - |
dc.identifier.orcid | Kennaway, D. [0000-0002-5864-3514] | - |
dc.identifier.orcid | Hiller, J. [0000-0002-8532-4033] | - |
dc.identifier.orcid | Robinson, J. [0000-0002-4515-6039] | - |
Appears in Collections: | Aurora harvest 2 Obstetrics and Gynaecology publications |
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