Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/23249
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Type: Journal article
Title: Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: A review
Author: Jacquet, J.
Begue, P.
Grimprel, E.
Reinert, P.
Sandbu, S.
Silfverdal, S.
Faldella, G.
Nolan, T.
Lambert, S.
Richmond, P.
Marshall, H.
Roberton, D.
Schuerman, L.
Citation: Vaccine, 2006; 24(13):2440-2448
Publisher: Elsevier Sci Ltd
Issue Date: 2006
ISSN: 0264-410X
1873-2518
Statement of
Responsibility: 
Jacquet, J.M. ; Bégué, P. ; Grimprel, E. ; Reinert, P. ; Sandbu, S. ; Silfverdal, S.A. ; Faldella, G. ; Nolan, T. ; Lambert, S. ; Richmond, P. ; Marshall, H. ; Roberton, D. ; Schuerman, L.
Abstract: A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines.
Keywords: immunogenicity
vaccine-associated adverse events
acellular pertussis vaccine
booster vaccination
DOI: 10.1016/j.vaccine.2005.12.009
Published version: http://dx.doi.org/10.1016/j.vaccine.2005.12.009
Appears in Collections:Aurora harvest 6
Paediatrics publications

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