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https://hdl.handle.net/2440/23249
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Type: | Journal article |
Title: | Safety and immunogenicity of a combined DTPa-IPV vaccine administered as a booster from 4 years of age: A review |
Author: | Jacquet, J. Begue, P. Grimprel, E. Reinert, P. Sandbu, S. Silfverdal, S. Faldella, G. Nolan, T. Lambert, S. Richmond, P. Marshall, H. Roberton, D. Schuerman, L. |
Citation: | Vaccine, 2006; 24(13):2440-2448 |
Publisher: | Elsevier Sci Ltd |
Issue Date: | 2006 |
ISSN: | 0264-410X 1873-2518 |
Statement of Responsibility: | Jacquet, J.M. ; Bégué, P. ; Grimprel, E. ; Reinert, P. ; Sandbu, S. ; Silfverdal, S.A. ; Faldella, G. ; Nolan, T. ; Lambert, S. ; Richmond, P. ; Marshall, H. ; Roberton, D. ; Schuerman, L. |
Abstract: | A combined DTPa-IPV booster vaccine was administered as a 4th or 5th dose after DTPa or DTPw priming. Over 99% vaccines developed antibody levels considered to be protective to diphtheria, tetanus and poliovirus, and >95% mounted a response to acellular pertussis antigens. Rectal temperature >39.5 degrees C was observed in at most 3.2% of vaccinees. Swelling >50 mm occurred in 24% of DTPa-primed compared to 5.5% of DTPw-primed children. Large swelling involving the entire upper arm (extending to involve the elbow joint) was reported for up to 1.2% of DTPa-primed subjects, which is consistent with literature reports for other DTPa vaccines. |
Keywords: | immunogenicity vaccine-associated adverse events acellular pertussis vaccine booster vaccination |
DOI: | 10.1016/j.vaccine.2005.12.009 |
Published version: | http://dx.doi.org/10.1016/j.vaccine.2005.12.009 |
Appears in Collections: | Aurora harvest 6 Paediatrics publications |
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