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https://hdl.handle.net/2440/23973
Type: | Journal article |
Title: | A community-based TB drug susceptibility study in Mimika district, Papua province, Indonesia |
Author: | Kelly, P. Ardian, M. Waramori, G. Anstey, N. Syahrial, H. Tjitra, E. Bastian, I. Maguire, G. Lumb, R. |
Citation: | International Journal of Tuberculosis and Lung Disease, 2006; 10(2):167-171 |
Publisher: | Int Union Against Tuberculosis Lung Disease (i U A T L D) |
Issue Date: | 2006 |
ISSN: | 1027-3719 1815-7920 |
Statement of Responsibility: | P. M. Kelly, M. Ardian, G. Waramori, N. M. Anstey, H. Syahrial, E. Tjitra, I. Bastian, G. P. Maguire, R. Lumb |
Abstract: | SETTING: A district level tuberculosis (TB) control programme in Papua Province, Indonesia. OBJECTIVE: To determine the nature and extent of drug-resistant TB in newly diagnosed sputum smear-positive patients. METHODS: Sputum was collected from previously untreated smear-positive pulmonary TB patients diagnosed in the district over a 10-month period. Sputum specimens were processed and inoculated into a BACTEC MGIT960 tube. Isolates were identified by Ziehl-Neelsen staining, hybridisation with nucleic acid probes and biochemical investigations. Susceptibility testing was performed using the radiometric proportion method. Pyrazinamide testing was performed using the Wayne indirect method. RESULTS: One hundred and seven patients had sputum sent to a reference laboratory; 101 (94.4%) were culture-positive for Mycobacterium tuberculosis, with 87 (86.1%) fully sensitive to first-line anti-tuberculosis drugs. Two per cent were multidrug-resistant (MDR-TB) and 12 (11.9%) had other drug resistance. Each of the MDR-TB isolates was susceptible to amikacin, capreomycin, ciprofloxacin and para-aminosalicylic acid (PAS), but were resistant to rifabutin. One isolate was also resistant to ethionamide. CONCLUSIONS: MDR-TB is present in Indonesia but is not a major problem for TB control in this district. Generalisability to other districts in Indonesia, particularly large urban areas, needs to be confirmed by future studies. |
Keywords: | tuberculosis Indonesia multi-drug resistance epidemiology survey |
Rights: | © 2006 Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article |
Published version: | http://adelaideaus.library.ingentaconnect.com/content/iuatld/ijtld/2006/00000010/00000002/art00009 |
Appears in Collections: | Aurora harvest 2 Molecular and Biomedical Science publications |
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