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https://hdl.handle.net/2440/27472
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Type: | Journal article |
Title: | Leukocytes on the move with phosphoinositide 3-kinase and its downstream effectors |
Author: | Procko, E. McColl, S. |
Citation: | BioEssays, 2005; 27(2):153-163 |
Publisher: | John Wiley & Sons, Inc. |
Issue Date: | 2005 |
ISSN: | 0265-9247 1521-1878 |
Abstract: | Cell signalling mediators derived from membrane phospholipids are frequent participants in biological processes. The family of phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol, generating second messengers that direct diverse responses. These PI3K products are fundamental for leukocyte migration or chemotaxis, a pivotal event during the immune response. This system is therefore of significant biomedical interest. This review focuses on the biochemistry and signalling pathways of PI3K, with particular emphasis on chemokine (chemotactic cytokine)-directed responses. The key objectives of chemotaxis are motility and direction. The latter--direction--requires distinct events at the front and back of a cell. In light of this, the coordinated localisation of signalling factors, an event choreographed by a sharp intracellular gradient of PI3K-derived products, is a common theme. |
Keywords: | Leukocytes Cell-Free System Animals Humans Phospholipids Chemokines Signal Transduction Cell Movement Chemotaxis Amino Acid Motifs Protein Structure, Tertiary Body Patterning Models, Biological Phosphatidylinositol 3-Kinases |
Description: | The definitive version may be found at www.wiley.com |
DOI: | 10.1002/bies.20157 |
Published version: | http://www3.interscience.wiley.com/journal/34201/home |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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