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https://hdl.handle.net/2440/27485
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dc.contributor.author | Matthews, G. | - |
dc.contributor.author | Cummins, A. | - |
dc.contributor.author | Lawrence, A. | - |
dc.contributor.author | Johnson, B. | - |
dc.contributor.author | Campbell, F. | - |
dc.contributor.author | Butler, R. | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Journal of Gastroenterology and Hepatology, 2005; 20(2):270-274 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | http://hdl.handle.net/2440/27485 | - |
dc.description.abstract | <h4>Background</h4>The purpose of the present paper was to assess the reproducibility of the (13)C-urea breath test ((13)C-UBT) and its ability to reflect the level of Helicobacter pylori-associated inflammation.<h4>Methods</h4>Asymptomatic H. pylori-positive subjects (n = 21) performed the (13)C-UBT six times. The H. pylori-positive symptomatic subjects (n = 55) performed the (13)C-UBT and had antral biopsies taken for histopathology, culture, urease activity assay and myeloperoxidase activity assay.<h4>Results</h4>No significant intraindividual variation in (13)C-UBT results were observed for the asymptomatic subjects. The (13)C-UBT results were significantly higher in symptomatic subjects with a moderate to severe gastritis compared to a mild gastritis and to no inflammation (34.5 +/- 4.4 vs 17.7 +/- 2.8 vs 1.7 +/- 0.1, respectively, P < 0.01). The (13)C-UBT results significantly correlated with urease (r = 0.55) and myeloperoxidase activity (r = 0.82) but not with bacterial load. conclusion: The (13)C-UBT is a reproducible determinant of H. pylori infection and non-invasively assesses the severity of antral inflammation. | - |
dc.description.statementofresponsibility | Matthews, Geoffrey M; Cummins, Adrian G; Lawrence, Andrew; Johnson, Bruce; Campbell, Fiona; Butler, Ross N | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Asia | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1440-1746.2005.03547.x | - |
dc.subject | Humans | - |
dc.subject | Helicobacter pylori | - |
dc.subject | Helicobacter Infections | - |
dc.subject | Urea | - |
dc.subject | Peroxidase | - |
dc.subject | Breath Tests | - |
dc.subject | Gastroscopy | - |
dc.subject | Severity of Illness Index | - |
dc.subject | Sensitivity and Specificity | - |
dc.subject | Reproducibility of Results | - |
dc.subject | Adolescent | - |
dc.subject | Adult | - |
dc.subject | Aged | - |
dc.subject | Aged, 80 and over | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | 13C-Urea breath test: Reproducibility and association with the severity of Helicobacter pylori-associated antral gastritis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1440-1746.2005.03547.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cummins, A. [0000-0003-3115-9498] | - |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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