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https://hdl.handle.net/2440/27525
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Type: | Journal article |
Title: | Effect of a synthetic progestin on the exercise status of sedentary young women |
Author: | Redman, L. Scroop, G. Westlander, G. Norman, R. |
Citation: | Journal of Clinical Endocrinology and Metabolism, 2005; 90(7):3830-3837 |
Publisher: | Endocrine Society |
Issue Date: | 2005 |
ISSN: | 0021-972X 0021-972X |
Statement of Responsibility: | Leanne M. Redman, Garry C. Scroop, Goran Westlander, and Robert J. Norman |
Abstract: | Context: The impact of progestins on exercise performance in women has not been previously studied. Objective: The objective of this study was to examine the effect of a synthetic progestin on aspects of exercise status in young women. Design, Patients, Setting: Twenty-three young, healthy, habitually sedentary women participated in a single-blind, randomized, counterbalanced, cross-over study in a university-based laboratory setting. Intervention: Two monophasic oral contraceptive pills (OCPs) were administered in which the dose of the synthetic progestin, norethisterone, was 2-fold different but the dose of the synthetic estrogen, ethinyl estradiol, was constant. During each month of OCP aspects of exercise status were assessed during incremental exercise to exhaustion and steady-state submaximal exercise and with a performance test. Main Outcome Measures: The main outcome measures were peak oxygen uptake (O2peak), respiratory exchange ratio (RER), time to exhaustion, lactate concentrations, and total work done. Results: Peak heart rates were approximately 95% of age-predicted values with both OCP preparations, whereas O2peak was approximately 30% above age-predicted values. Peak postincremental exercise plasma lactate concentrations exceeded those reported for males and females, whereas the RER was below expected values throughout both incremental and steady-state exercise. The effects on O2peak and RER were increased with the higher dose progestin OCP, as were exercise time to exhaustion and total work done. |
Keywords: | Humans Carbon Dioxide Lactic Acid Progesterone Congeners Contraceptives, Oral Exercise Cross-Over Studies Oxygen Consumption Respiration Adult Female |
Description: | Copyright © 2005 by The Endocrine Society |
DOI: | 10.1210/jc.2004-2401 |
Published version: | http://dx.doi.org/10.1210/jc.2004-2401 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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