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https://hdl.handle.net/2440/27578
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Type: | Journal article |
Title: | Inducible serum resistance in Salmonella typhimurium is dependent on wzzfepE-regulated very long O antigen chains |
Author: | Murray, G. Attridge, S. Morona, R. |
Citation: | Microbes and Infection: a journal on infectious agents and host defenses, 2005; 7(13):1296-1304 |
Publisher: | Editions Scientifiques Medicales Elsevier |
Issue Date: | 2005 |
ISSN: | 1286-4579 1769-714X |
Abstract: | Salmonella typhimurium possesses two wzz genes conferring long (wzzST) and very long (wzzfepE) lipopolysaccharide O antigen modal chain lengths. While the long O antigen modal length was essential for complement resistance, the very long modal length was found to have a minor role. However, when grown in the presence of serum, S. typhimurium demonstrated a wzzfepE-dependent increase in the density of very long O antigen chains, resulting in a significant increase in serum resistance. Similar phenotypic changes were observed after growth under iron-limiting conditions, though iron limitation is unlikely to be the sole signalling mechanism behind the changes induced in serum. A wzzfepE::lacZ promoter fusion was used to determine that regulation of wzzfepE transcription is unlikely to be the mechanism behind the variation in O antigen length. Since systemic infection occurs in a small but significant percentage of human non-typhoid salmonellosis, the phenomenon identified in this study may be significant during the bacteraemic phase of infection. |
Keywords: | Salmonella typhimurium Serum complement Lipopolysaccharide O antigen Bacteraemia Adaptation wzzfepE |
Rights: | Copyright © 2005 Elsevier SAS All rights reserved. |
DOI: | 10.1016/j.micinf.2005.04.015 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/601557/description#description |
Published version: | http://dx.doi.org/10.1016/j.micinf.2005.04.015 |
Appears in Collections: | Aurora harvest 6 Molecular and Biomedical Science publications |
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